67188-08-3Relevant academic research and scientific papers
POLYMERIZABLE LIQUID CRYSTAL COMPOUND, COMPOSITION, LIQUID CRYSTAL POLYMERIZATION FILM-KIND THEREOF AND USE THEREOF
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Paragraph 0315; 0317, (2017/07/14)
An object is to provide a polymerizable liquid crystal compound, a polymerizable liquid crystal composition containing the compound and liquid crystal polymerization film-kind capable of controlling chromatic dispersion characteristics and having low posi
Synthesis of quinolines through copper-catalyzed intermolecular cyclization reaction from anilines and terminal acetylene esters
Zheng, Zhilei,Deng, Guobo,Liang, Yun
, p. 103478 - 103481 (2016/11/13)
A simple and convenient copper-catalyzed intermolecular cyclization reaction for the synthesis of quinolines from anilines and terminal acetylene esters has been developed. This methodology constructs the C-N and C-C bonds successively via a cascade process, and provides the desired products in moderate to good yields.
Discovery of quinolinediones exhibiting a heat shock response and angiogenesis inhibition
Hargreaves, Robert H. J.,David, Cynthia L.,Whitesell, Luke J.,LaBarbera, Daniel V.,Jamil, Akmal,Chapuis, Jean C.,Skibo, Edward B.
, p. 2492 - 2501 (2008/12/21)
A series of substituted quinoline-5,8-diones were synthesized and evaluated as inhibitors of the chaperone protein Hsp90 using two assays: competition for binding to C-terminal ATP-binding site and competition for binding to N-terminal ATP-binding site. I
Chemoselective arylamination of β-bromovinylaldehydes followed by acid catalyzed cyclization: a general method for polycyclic quinolines
Some, Surajit,Ray, Jayanta K.
, p. 5013 - 5016 (2008/02/10)
A synthesis of polycyclic quinolines is described via palladium-catalyzed chemoselective arylamination of β-bromovinylaldehydes with aromatic amines followed by acid catalyzed cyclization.
Design of quinolinedione-based geldanamycin analogues
Hargreaves, Robert,David, Cynthia L.,Whitesell, Luke,Skibo, Edward B.
, p. 3075 - 3078 (2007/10/03)
Quinoline-5,8-dione-based compounds were designed from the structure of the geldanamycin-bound Hsp-90 active site. The active site model predicted that aromatic substituents should be present at the 2-position, to take advantage of a hydrophobic pocket, a
Incorporation of Quinoline-5,8-quinone Moiety into Polyaza Cavities
Thummel, Randolph P.,Chirayil, Sara,Hery, Christophe,Lim, Jean-Luc,Wang, Tie-Lin
, p. 1666 - 1671 (2007/10/02)
Silica gel supported nitric acid treatment of 2,5-dimethoxybenzaldehyde followed by reduction with iron powder provides 3,6-dimethoxy-2-aminobenzaldehyde.Friedlaender condensation of this species with a variety of ketones and diketones leads to 5,8-dimethoxyquinoline derivatives which may be oxidized by ceric ammonium nitrate (CAN) and pyridine-2,6-dicarboxylic acid N-oxide (PDANO) to the corresponding quinones.The quinone functionality can be incorporated into larger cavities by a selective stepwise Friedlaender approach and the CAN/PDANO oxidation appears to work preferentially for 5,8-dimethoxyquinoline.
