77242-30-9

Usage

Uses

Used in Pharmaceutical Synthesis:
2-amino-5-nitrobenzyl alcohol is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to participate in a range of chemical reactions, contributing to the development of new drugs and medical treatments.
Used in Organic Synthesis:
As a versatile intermediate, 2-amino-5-nitrobenzyl alcohol is employed in organic synthesis for the production of a variety of organic compounds, leveraging its reactivity and functional groups.
Used in Specialty Chemicals Production:
2-amino-5-nitrobenzyl alcohol is used as a starting material or intermediate in the production of dyes, pigments, and other specialty chemicals, where its unique properties are harnessed to create specific colorants and compounds.
Used in Research and Development:
In the scientific community, 2-amino-5-nitrobenzyl alcohol serves as a valuable compound in research and development, particularly in exploring new chemical reactions and potential applications in various industries.

InChI:InChI=1/C7H8N2O3/c8-7-2-1-6(9(11)12)3-5(7)4-10/h1-3,10H,4,8H2

Upstream product

• 91538-60-2 N-(2-formyl-4-nitrophenyl)acetamide 
• 5344-90-1 2-Aminobenzyl alcohol 
• 83326-80-1 N-acetyl-O-acetyl-2-aminobenzyl alcohol 
• 616-79-5 2-amino-5-nitro-benzoic acid 
• 3816-62-4 5-nitroanthranilic acid methyl ester 
• 118-48-9 isatoic anhydride 
• 4693-02-1 6-nitroisatoic anhydride 
• 56008-61-8 2-amino-5-nitrobenzaldehyde 

Downstream Products

• 39224-61-8 2-hydroxy-5-nitrobenzyl alcohol 
• 73793-80-3 2-hydroxymethyl-1,4-diaminobenzene 
• 861222-14-2 acetic acid-(2-hydroxymethyl-4-nitro-anilide) 
• 94107-60-5 6-nitro-1H-benzo[d][1,3]oxazin-2(4H)-one 
• 1214247-96-7 2-(tert-butyl-dimethyl-silanyloxymethyl)-4-nitro-phenylamine 
• 67199-66-0 batracylin 
• 1371596-68-7 (E)-2,2'-(4-((2-(hydroxymethyl)-4-nitrophenyl)diazenyl)phenylazanediyl)diethanol 
• 337906-36-2 2-(methoxymethyl)-p-phenylenediamine 
• 337906-35-1 2-(methoxymethyl)-4-nitroaniline 
• 56008-61-8 2-amino-5-nitrobenzaldehyde 

Relevant academic research and scientific papers

Facile Access to Triazole-Fused 3,1-Benzoxazines Enabled by Metal-Free Base-Promoted Intramolecular C-O Coupling

A convenient approach to assemble 1,2,3-triazole-fused 4 H -3,1-benzoxazines has been developed. Diverse alcohol-tethered 5-iodotriazoles, readily accessible by a modified protocol of Cu-catalyzed (3+2)-cycloaddition, were utilized as precursors of the target fused heterocycles. The intramolecular C-O coupling proceeded efficiently under base-mediated transition-metal-free conditions, furnishing cyclization products in yields up to 96%. Suppression of the competing reductive cleavage of the C-I bond was achieved by the use of Na 2CO 3in acetonitrile at 100 °C. This practical and cost-effective procedure features a broad substrate scope and valuable functional group tolerance.

FACTOR XIa INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

Process for Preparing Primary Intermediates for Dyeing Keratin Fibers

A process has been developed for preparing 2-methoxymethyl-1,4-benzenediamine (IV-a), other compounds of formula (IV), and the salts thereof, all of which may be used as primary intermediates in compositions for dyeing keratin fibers.

Process for Preparing Primary Intermediates for Dyeing Keratin Fibers

A process has been developed for preparing 2-methoxymethyl-1,4-benzenediamine (IV-a), other compounds of formula (IV), and the salts thereof, all of which may be used as primary intermediates in compositions for dyeing keratin fibers.

Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands

We have reported previously the novel δ opioid agonist KNT-127 which showed high affinity and selectivity for the δ receptor. Moreover, the analgesic effect of subcutaneously administered KNT-127 was more potent than that of a prototypical δ agonist (-)-TAN-67 in the acetic acid writhing test. This study of the structure-activity relationship of KNT-127 derivatives focused on the introduction of substituents onto the 5′-, 6′-, 7′- or 8′-position of the quinoline ring and revealed that many derivatives with 5′- or 8′-substituents showed high affinities and selectivities for the δ receptor. Especially, SYK-153 with an 8′-OH group showed the highest affinity and the most balanced and highest selectivity for the δ receptor among the synthesized compounds.

A concise and cascade synthesis of batracylin and substituted isoindolo-[1,2- b ]quinazolin-12(10 H)-ones

A concise, highly convergent, and practical synthesis of the clinical-phase anticancer agent batracylin in a two-stage process in excellent yield is described. The B and C rings of this tetracyclic heterocycle are constructed by cascade cyclization of 5-nitro-2-aminobenzyl alcohol with 2-cyanomethyl benzoate in trifluoroacetic acid in good yield in a single-pot reaction. A plausible mechanism for the cascade reaction is also proposed. As part of these studies, a range of batracylin derivatives with different substituents on the C and D rings are synthesized. Georg Thieme Verlag Stuttgart.

6-SUBSTITUTED BENZOXAZINES

The present invention is concerned with 6-substituted benzoxazine derivatives of formula (I) wherein X, Y, R1 and R2 are as described herein, their manufacture, and pharmaceutical compositions containing them. The active compounds of the present invention are 5-HT5A receptor antagonists, useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders, Parkinson's disease, psychiatric disorders or gastrointestinal disorders.

Synthesis of substituted indole from 2-aminobenzaldehyde through [1,2]-aryl shift

A mild, efficient, and simple method for the synthesis of 3-ethoxycarbonylindoles has been developed. Addition of ethyl diazoacetate (EDA) to 2-aminobenzaldehydes cleanly affords the indole core. As opposed to other common approaches for the synthesis of indole, this method displays both excellent functional group tolerance and perfect regiochemical control. This allowed the synthesis of a variety of useful indole building blocks from 2-aminobenzaldehydes derived from readily available anthranilic acids.

Novel imidazole derivatives

Disclosed are novel imidazole derivatives having the formula: STR1 wherein R1 and R2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R1 and R2 are combined to form a heterocyclic ring; R3, R4, R5 and R6 are H, halogen, alkoxy, aralkyloxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, or fluorine substituted-alkoxy, or R3 is combined with R2 to form a heterocyclic ring; R8 and R9 are H, halogen, alkoxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, fluorine substituted-alkoxy, or aryl group which may have a substituent, or R8 and R9 are combined to form an alicyclic ring; R7 is, where R8 and R9 are not combined, H, and, where R8 and R9 are combined, H, alkyl which may have a substituent, aryl which may have a substituent, arylcarbonyl which may have a substituent, or a sulfur-containing heterocyclic group; and n is 0 or 1. The new imidazole derivatives are effective particularly as anti-ulcer agents.

1,3-Benzoxazine trichloromethyl derivatives, compositions and use

The invention relates to novel heterocyclic trichloromethyl derivatives, particularly 2-trichloromethyl-substituted quinazoline, benzo[d]-[1,3]-oxazine and benzo[e]-[1,3]-oxazine derivatives, for example 1,2-dihydro-2-trichloromethylquinazolin-4-one. The compounds of the invention are at least as effective as prior art trichloromethyl derivatives, which reduce the production of methane during the rumen metabolism of ruminant animals, and increase the formation of propionate at the expense of acetate, and hence improve the animals' rate of growth and their efficiency of food utilization.