672-31-1

Usage

Uses

Used in Pharmaceutical Industry:
3-(Pentafluorosulfanyl)phenol is used as an intermediate compound for the synthesis of pyrimidine compounds, which are essential in the treatment and/or diagnosis of seizure disorders. Its unique chemical properties allow for the development of novel therapeutic agents that can potentially improve the management of seizures and related conditions.

InChI:InChI=1/C6H5F5OS/c7-13(8,9,10,11)6-3-1-2-5(12)4-6/h1-4,12H

Upstream product

• 1272542-23-0 1-methoxy-3-(pentafluorosulfanyl)benzene 
• 2613-26-5 3-nitrophenylsulfur pentafluoride 
• 2993-22-8 3-pentafluorosulfuraniline 

Downstream Products

• 845882-08-8 5-methanesulfonyl-2-methyl-4-(3-pentafluorosulfanyl-phenoxy)-benzoic acid methyl ester 
• 1246998-17-3 3-(pentafluorosulfanyl)phenyl trifluoromethane-sulfonate 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF 3- AND 4-(PENTAFLUOROSULFANYL)BENZENES

Process for the preparation of substituted 3- and 4-(pentafluorosulfanyI)benzenes of general formula 3 and 4 by nucleophilic aromatic substitution, where nitrobenzene having pentafiuorosulfanyl group connected in position 3 or 4 is allowed to react in concentration range 0.01 to 8.0 mol.l-1 with compound RY-M+, where R is selected from a group comprising saturated, unsaturated, acyclic, cyclic or aromatic, substituted or unsubstituted carbon chain, Y is the element of VI. B group and M+ is the metal ion, in an organic solvent. The invention includes also further chemical modifications of primary products.

SNAr reactions of nitro-(pentafluorosulfanyl)benzenes to generate SF5 aryl ethers and sulfides

Nucleophilic aromatic substitution of the nitro group of para- and meta-nitro-(pentafluorosulfanyl)benzene with alkoxides and thiolates generates a range of substituted 4- and 3-(pentafluorosulfanyl)benzenes in a single-step reaction.

ORTHO-SUBSTITUTED PENTAFLUOROSULFANYL BENZENES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS SYNTHESIS INTERMEDIATES

This invention relates to novel substituted pentafluorosulfanylbenzenes of the formula I: and/or salts thereof as claimed, for use as a synthetic intermediates for preparing medicaments, diagnostic aids, liquid crystals, pesticides, herbicides, fungicides, nematicides, parasiticides, insecticides, acaricides, arthropodicides and polymers.

Pentafluorosulfanylphenyl-substituted benzoylguanidines, method for the production thereof, their use as a medicament or diagnostic agent, and a medicament containing these compounds

The invention relates to pentafluorosulfanylphenyl-substituted benzoylguanidines of the formula I: and a process for preparing a compound of the formula I and/or the pharmaceutically acceptable salts thereof.

ORTHO-SUBSTITUTED PENTAFLUOROSULFANYL BENZENES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS SYNTHESIS INTERMEDIATES

The invention relates to pentafluorosulfanyl benzenes of formula (I) in which R1 to R5 have the meanings as cited in the claims, which depict valuable intermediates, e.g. for producing medicaments, diagnostic agents, liquid crystals, pesticides, herbicides, fungicides, nematicides, parasiticides, insecticides, acaricide, arthropodicides and polymers.

PENTAFLUOROSULFANYLPHENYL-SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICAMENT OR DIAGNOSTIC AGENT, AND A MEDICAMENT CONTAINING THESE COMPOUNDS

The invention relates to pentafluorosulfanylphenyl-substituted benzoylguanidines, to a method for the production thereof, to their use as a medicament or diagnostic agent, and to a medicament containing these compounds. These pentafluorosulfanylphenyl-sub

Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them

Pentafluorosulfanylphenyl-substituted benzoylguanidines of the formulae I and II in which R1, R1′, R2, R2′, R3, R3′, R4 and X have the meanings indicated in the claims, are suitable as antiarrhythmic medicaments with a cardioprotective component for the prophylaxis of infarction and treatment of infarction and for the treatment of angina pectoris. They also inhibit preventively the pathophysiological processes associated with the development of ischemia-induced damage, especially in the triggering of ischemia-induced cardiac arrhythmias.

Synthesis of some arylsulfur pentafluoride pesticides and their relative activities compared to the trifluoromethyl analogues

Examples of pesticides containing an arylsulfur pentafluoride group were made and their biological activities compared to the corresponding trifluoromethyl analogues. A phenylsulfur pentafluoride analogue of the insecticide fipronil, screened against a resistant strain of Musca domestica, showed higher activity than the corresponding trifluoromethyl analogue.