672-41-3

Usage

Uses

Used in Pharmaceutical Industry:
6-Trifluoromethyl pyrimidin-4-ylamine is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drug compounds with potential therapeutic applications.
Used in Agrochemical Industry:
6-Trifluoromethyl pyrimidin-4-ylamine is used as an intermediate in the synthesis of agrochemicals to develop new compounds for agricultural applications, such as pesticides or herbicides.
Used in Organic Chemistry Research:
6-Trifluoromethyl pyrimidin-4-ylamine is used as a building block in organic chemistry for its unique structure and properties, enabling the exploration of new chemical reactions and the synthesis of novel compounds.
Used in Medicinal Chemistry Research:
6-Trifluoromethyl pyrimidin-4-ylamine is used in medicinal chemistry research for its potential role in the development of kinase inhibitors, which are important in the treatment of various diseases, including cancer. Its unique structure allows for the design and synthesis of new compounds with improved pharmacological properties.

Upstream product

• 1546-78-7 4-trifluoromethyl-1,6-dihydropyrimidine-6-oxide 
• 1513-72-0 4-amino-6-trifluoromethyl-1H-pyrimidine-2-thione 
• 37552-81-1 4-chloro-6-(trifluoromethyl)pyrimidine 
• 368-54-7 2-sulfanylidene-6-(trifluoromethyl)-2,3-dihydropyrimidin-4(1H)-one 
• 1546-78-7 6-trifluoromethyl-4-hydroxypyrimidine 
• 7664-41-7 ammonia 

Relevant academic research and scientific papers

CYCLOPROPANECARBOXAMIDO-SUBSTITUTE AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS

Provided are cyclopropanecarboxamido-substituted aromatic compounds that inhibit protein kinases and their use in anti-tumor area. In particular, tyrosine-kinase inhibitors and Raf-kinase inhibitors as anti-tumor agents, their preparation, pharmaceutical composition, and their use in the treatment of cancer are also provided.

THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS

The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, and R4 are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).

CYCLOPROPANECARBOXAMIDO-SUBSTITUTE AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS

Provided are cyclopropanecarboxamido-substituted aromatic compounds that inhibit protein kinases and their use in anti-tumor area. In particular, tyrosine-kinase inhibitors and Raf-kinase inhibitors as anti-tumor agents, their preparation, pharmaceutical composition, and their use in the treatment of cancer are also provided.

QUINAZOLINONE DERIVATIVES HAVING B-RAF INHIBITORY ACTIVITY

The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

QUINAZOLIN-4-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B-Raf inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.

SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS

Substituted pyrimidine derivatives of formula (I), salts, metabolites, prodrugs and diastereoisomeric forms (both isolated stereoisomers and mixtures of stereoisomers) thereof (wherein A= pyrimidine) pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with other active ingredients, e.g., cytotoxic therapies.