6720-39-4

Upstream product

• 623-10-9 N-(4-methylphenyl)hydroxylamine 
• 222851-56-1 N-phenylsulfinylamine 
• 71-43-2 benzene 
• 65578-58-7 di-tert-butyl 1-phenylhydrazine-1,2-dicarboxylate 
• 624-31-7 4-tolyl iodide 
• 106-49-0 p-toluidine 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 62-53-3 aniline 
• 99-99-0 1-methyl-4-nitrobenzene 
• 98-95-3 nitrobenzene 
• 621-94-3 1-(4-methylphenyl)-2-phenylhydrazine 
• 949-87-1 4-Methylazobenzol 
• 586-96-9 Nitrosobenzene 
• 3958-47-2 triphenylindium 

Downstream Products

• 927896-38-6 (E)-1-(2-iodo-4-methylphenyl)-2-phenyldiazene 
• 3682-80-2 2H-2-(4-methylphenyl)benzo[d]-1,2,3-triazole 
• 38610-46-7 5-methyl-2-phenyl-2H-benzo[d][1,2,3]triazole 
• 666238-00-2 W(OC₆H(phenyl)4-2,3,5,6)2(N(4-methylphenyl))(N(phenyl))(trimethylphosphine) 
• 876479-63-9 acetic acid-(N'-phenyl-N-p-tolyl-hydrazide) 
• 426224-80-8 N-(Azobenzene-4-ylmethyl)-5-dimethylaminonaphthalene-N-propyl-1-sulfonamide 
• 106-49-0 p-toluidine 
• 62-53-3 aniline 
• 6720-28-1 cis-4-methylazobenzene 
• 108-88-3 toluene 
• 71-43-2 benzene 
• 145585-58-6 (E)-1-(4-(bromomethyl)-phenyl)-2-phenyldiazene 

Relevant academic research and scientific papers

Chemoselective Hydrogenation of Nitroarenes Using an Air-Stable Base-Metal Catalyst

The reduction of nitroarenes to anilines as well as azobenzenes to hydrazobenzenes using a single base-metal catalyst is reported. The hydrogenation reactions are performed with an air-and moisture-stable manganese catalyst and proceed under relatively mild reaction conditions. The transformation tolerates a broad range of functional groups, affording aniline derivatives and hydrazobenzenes in high yields. Mechanistic studies suggest that the reaction proceeds via a bifunctional activation involving metal-ligand cooperative catalysis.

Calculated oxidation potentials predict reactivity in Baeyer-Mills reactions

Azobenzenes are widely used as dyes and photochromic compounds, with the Baeyer-Mills reaction serving as the most common method for their preparation. This transformation is often plagued by low yields due to the formation of undesired azoxybenzene. Here, we explore electronic effects dictating the formation of the azoxybenzene side-product. Using calculated oxidation potentials, we were able to predict reaction outcomes and improve reaction efficiency simply by modulating the oxidation potential of the arylamine component.

Oxidative dehydrogenation of hydrazines and diarylamines using a polyoxomolybdate-based iron catalyst

We report an efficient method for the oxidative dehydrogenation of hydrazines and diarylamines in aqueous ethanol using Anderson-type polyoxomolybdate-based iron(iii) as a catalyst and hydrogen peroxide as an oxidant. A series of azo compounds and tetraarylhydrazines were obtained in moderate to excellent yields. The reaction conditions and substrate scopes are complementary or superior to those of more established protocols. In addition, the catalyst shows good stability and reusability in water. The preliminary mechanistic studies suggest that a radical process is involved in the reaction.

Photochromic controlled permeable small molecule cross-linked vesicle as well as preparation method and application thereof

The invention discloses a photochromic controlled-permeation small-molecule crosslinked vesicle CSMVs as well as a preparation method and application thereof. Belong to micromolecule self-assembly technical field. The invention firstly synthesizes an azobenzene amphiphilic compound, and then further cross-linking to prepare the photochromic controllable permeable small-molecule cross-linked vesicle. The controlled release system is simple to prepare, high in stability, intelligent in control, and capable of exhibiting real-time controllable permeability in time and space, CSMVs at the molecular level due to the molecular structure of the vesicle wall, and instantaneous controlled release is exhibited. In cancer. The method has wide application prospects in the accurate treatment of diseases such as diabetes and bacterial infection.

NIR-responsive reversible phase transition of supramolecular hydrogels for tumor treatment

Locally administrable drugs with controllable release on external cues hold great promise for antitumor therapy. Here, we report an injectable, supramolecular hydrogel (SHG), where the drug release can be controllably driven by near infrared (NIR) irradia

Photoswitchable Inhibitor of the Calcium Channel TRPV6

Herein we report the first photoswitchable inhibitor of Transient Receptor Potential Vanilloid 6 (TRPV6), a selective calcium channel involved in a number of diseases and in cancer progression. By surveying analogs of a previously reported TRPV6 inhibitor appended with a phenyl-diazo group, we identified a compound switching between a weak TRPV6 inhibitor in its dark, E-diazo stereoisomer (Z/E = 3:97, IC50 ? 10 μM) and a potent inhibitor as the Z-diazo stereoisomer accessible reversibly by UV irradiation at λ = 365 nm (Z/E = 3:1, IC50 = 1.7 ± 0.4 μM), thereby allowing precise spatiotemporal control of inhibition. This new tool compound should be useful to deepen our understanding of TRPV6.

Photo-controlled reversible secondary self-assembly of supramolecular nanosheets and their drug delivery behavior

Supramolecular nano-drug delivery systems with stimuli-responsive features have attracted extensive attention in photodynamic therapy. In this work, a new kind of photo-controlled reversible two dimensional (2D) nanosheet was constructed by cucurbit[8]uri

Electrochemical dehydrogenation of hydrazines to azo compounds

A strategy for the electrochemical dehydrogenation of hydrazine compounds is disclosed under ambient conditions. This protocol proceeded smoothly in ethanol by employing electrons as clean oxidants. Its synthetic value is well demonstrated by the highly efficient synthesis of symmetric and unsymmetric azo compounds. It is an environmentally friendly transformation and the present protocol was effective on a large scale.

Dehydrogenation of the NH?NH Bond Triggered by Potassium tert-Butoxide in Liquid Ammonia

A novel strategy for the dehydrogenation of the NH?NH bond is disclosed using potassium tert-butoxide (tBuOK) in liquid ammonia (NH3) under air at room temperature. Its synthetic value is well demonstrated by the highly efficient synthesis of aromatic azo compounds (up to 100 % yield, 3 min), heterocyclic azo compounds, and dehydrazination of phenylhydrazine. The broad application of this strategy and its benefit to chemical biology is proved by a novel, convenient, one-pot synthesis of aliphatic diazirines, which are important photoreactive agents for photoaffinity labeling.

Volume Conserving Geometric Isomerization of Encapsulated Azobenzenes in Ground and Excited States and as Radical Ion

To probe the role of the supramolecular steric effects and free volume on photoreactions, geometric isomerization of neutral azobenzenes (ABs) and their radical ions, generated by electron transfer with gold nanoparticles, included within an octa acid capsule, was investigated. A comparison of the isomerization of ABs that proceed by volume conserving pyramidalization and stilbene analogues that proceed by volume demanding one bond flip has indicated the differing influence of 4-alkyl groups on these two processes.