67205-66-7 Usage
Uses
Used in Pharmaceutical Industry:
2-(Methylamino)-3,5,6-trifluoro-1,4-benzenedicarbonitrile is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and properties allow for the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical industry, 2-(Methylamino)-3,5,6-trifluoro-1,4-benzenedicarbonitrile serves as a crucial building block for the synthesis of novel pesticides. Its stability and low water solubility contribute to the enhanced performance and environmental compatibility of the resulting agrochemicals.
Used in Organic Synthesis:
2-(Methylamino)-3,5,6-trifluoro-1,4-benzenedicarbonitrile is utilized as a versatile starting material in organic synthesis for the preparation of a wide range of organic molecules. Its basic properties and fluoro-substitution enable the formation of various functional groups and molecular architectures, expanding the scope of synthetic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 67205-66-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,2,0 and 5 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 67205-66:
(7*6)+(6*7)+(5*2)+(4*0)+(3*5)+(2*6)+(1*6)=127
127 % 10 = 7
So 67205-66-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H4F3N3/c1-15-9-5(3-14)7(11)6(10)4(2-13)8(9)12/h15H,1H3
67205-66-7Relevant academic research and scientific papers
Synthesis and antiinflammatory evaluation of substituted isophthalonitriles, trimesonitriles, benzonitriles, and terephthalonitriles
Heilman,Battershell,Pyne,Goble,Magee
, p. 906 - 913 (2007/10/06)
In an effort to develop nonacidic, nonsteroidal, antiinflammatory agents without gastrointestinal complications, a series of cyanobenzenes was synthesized for antiinflammatory evaluation. Twenty-seven substituted isophthalonitriles, 19 trimesonitriles, 30 benzonitriles, and 16 terephthalonitriles were tested in the rat utilizing the carrageenan-induced pedal edema assay. Based on the performance of phenylbutazone in this assay (43.8% reduction at 100 mg/kg), six compounds, dosed at 50 mg/kg, produced reductions in inflammation comparable to this standard. However, the LD50 value of each compound dosed at this level was in the range of 40-56 mg/kg in the mouse; therefore, further study was not warranted. Fifteen compounds possessed activity in excess of 20% reduction at 200 mg/kg and also possessed LD50 values greater than 300 mg/kg. Of these cyanobenzenes, trimesonitrile, 4-chlorobenzonitrile, 2-chloroterephthalonitrile, and 2-fluoroterephthalonitrile with reductions in edema of 32, 30, 46, and 49%, respectively, represent the best candidates for subsequent study.
