672314-40-8Relevant articles and documents
Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl) cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters
Gingras, Karine,Avedissian, Hovsep,Thouin, Eryk,Boulanger, Véronique,Essagian, Charles,McKerracher, Lisa,Lubell, William D.
, p. 4931 - 4934 (2007/10/03)
The influence of stereochemistry and alkyl side chain length on the bioactivity of the Rho kinase inhibitor Y-27632 [(+)-1, R = Me] was examined by the synthesis of (+)- and (-)-1, and two alkyl chain analogs (+)- and (-)-2 (R = n-propyl) and (-)-3 (R = n