67250-22-0

Upstream product

• 50-00-0 formaldehyd 
• 28143-91-1 (1S,2S)-2-amino-1-phenyl-1,3-diol 

Downstream Products

• 104196-23-8 (2S,3S)-2,3-epoxy-3-phenyl-1-propanol 
• 21915-53-7 (2R,3S)-(3-phenyloxiran-2-yl)methanol 
• 91420-77-8 Formic acid (2S,3S)-3-phenyl-oxiranylmethyl ester 
• 91420-77-8 Formic acid (2R,3S)-3-phenyl-oxiranylmethyl ester 
• 91420-78-9 (S)-((R)-oxiran-2-yl)(phenyl)methanol 
• 1356938-67-4 (+)-(1S,2S)-N-(1,3-dihydroxy-1-phenylpropan-2-yl)-N,N-dimethylhexadecan-1-ammonium bromide 
• 906548-48-9 C₁₀H₁₆O₂*C₁₁H₁₇NO₂ 

Relevant academic research and scientific papers

New chiral ligand for optically active β-Hydroxy esters synthesis by enantioselective reformatsky reactions

The cheap commercially available (1S,2S)-1-phenyl-2-amino-1,3-propanediol 2 appears to be a convenient precursor for the synthesis of chiral auxiliaries for the preparation of optically active P-hydroxy esters by asymmetric Reformatsky reactions. The N,N-

Deracemization of bilirubin as the marker of the chirality of micellar aggregates

The deracemization of bilirubin in micellar aggregates of structurally correlated chiral surfactants was studied by circular dichroism experiments and exploited as the marker of the expression of chirality of the aggregates. The obtained results suggest that the hydrophobic interactions control the transfer of chirality from the monomers to the aggregates, and that different regions of the same aggregate might feature opposite enantiorecognition capabilities.

PROCESS FOR OBTAINING ENANTIOMERS OF CHRYSANTHEMIC ACID

A new process is described, easy to perform on industrial scale, with high yield, for obtaining enantiomers of chrysanthemic acid starting from mixtures containing them. The process involves reacting said mixtures with enantiomers of 2- dimethylamino-1-phenyl-1 ,3-propanediol (DMPP) and 2-dimethylamino-1-[4- (methylthio)phenyl]propane-1 ,3-diol (MTDP) as chiral selectors. The invention includes salts of chrysanthemic acid with the aforesaid chiral selectors as process intermediates. The process allows operation in a single solvent rather than in solvent mixtures difficult to recover and reuse, and the final crystallization product does not incorporate molecules of solvent. The bases used are then recovered and reused in subsequent separations.