67264-28-2

Upstream product

• 3453-00-7 diethyl benzoylmethylphosphonate 
• 1207456-20-9 tert-butyl 2-(diethoxyphosphoryl)-1-phenylethylcarbamate 
• 100-42-5 styrene 
• 72019-14-8 (2-hydroxy-2-phenyl-ethyl)-phosphonic acid diethyl ester 
• 70-11-1 α-bromoacetophenone 
• 88184-66-1 C₁₀H₁₀BrNO₂ 
• 683-08-9 Diethyl methylphosphonate 
• 100-47-0 benzonitrile 
• 152801-76-8 {2-[(Z)-Methoxyimino]-2-phenyl-ethyl}-phosphonic acid diethyl ester 
• 88184-60-5 C₁₄H₂₀NO₅P 

Downstream Products

• 59374-52-6 2-amino-2-phenylethylphosphonic acid 

Relevant academic research and scientific papers

Mn(III)-mediated phosphonation-azidation of alkenes: A facile synthesis of β-azidophosphonates

A new and general method for the synthesis of β-azidophosphonates has been achieved through Mn(OAc)3-mediated radical oxidative phosphonation-azidation of alkenes. The starting materials of P(O)-H compounds, alkenes, and azidotrimethylsilane are stable and cheap. This method can be easily adapted for large-scale preparation.

Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase

The human farnesyl pyrophosphate synthase (hFPPS), a key regulatory enzyme in the mevalonate pathway, catalyzes the biosynthesis of the C-15 isoprenoid farnesyl pyrophosphate (FPP). FPP plays a crucial role in the post-translational prenylation of small GTPases that perform a plethora of cellular functions. Although hFPPS is a well-established therapeutic target for lytic bone diseases, the currently available bisphosphonate drugs exhibit poor cellular uptake and distribution into nonskeletal tissues. Recent drug discovery efforts have focused primarily on allosteric inhibition of hFPPS and the discovery of non-bisphosphonate drugs for potentially treating nonskeletal diseases. Hit-to-lead optimization of a new series of thienopyrimidine-based monosphosphonates (ThP-MPs) led to the identification of analogs with nanomolar potency in inhibiting hFPPS. Their interactions with the allosteric pocket of the enzyme were characterized by crystallography, and the results provide further insight into the pharmacophore requirements for allosteric inhibition.

A β - hydroxyalkanephosphonic ester derivatives

The invention discloses a preparation method of beta-hydroxyphosphonate derivatives. The preparation method comprises that an arylethene derivative, a phosphorus reagent and manganese acetate are dissolved in a solvent and the solution undergoes a reactio

Asymmetrie synthesis of α,β-Diaminophosphonic acid derivatives with a catalytic enantioselective mannich reaction

Optically active α,β-diaminophosphonic acid derivatives were obtained from the catalytic enantioselective Mannich reaction of phosphoglycine Schiff bases with N-Boc-imines, generated in situ from a-amido sulfones.

Synthesis of β-amino phosphonates in one-pot procedure

β-Amino phosphonate derivatives are synthesized in one-pot procedure via reduction of β-amino phosphonate intermediates with NaBH4/acetic acid or trifluoroacetic acid.

Synthesis and properties of 2-amino-2-arylethylphosphonic acids and derivatives

2-Amino-2-arylethylphosphonic acids, 6a to 6q have been prepared from the corresponding 2-acetoxyimino-or 2-methoxy imino-2-arylethylphosphonates, 3 or 4, by hydrogenation using Raney-Ni as a catalyst, followed by hydrolysis with HCl. 3 and 4 were obtaine

ORGANIC PHOSPHORUS COMPOUNDS 105 SYNTHESIS AND PROPERTIES OF 2-AMINO-2-ARYLETHYLPHOSPHONIC ACIDS AND DERIVATIVES

2-Amino-2-arylethylphosphonic acids, 6a to 6q have been prepared from the corresponding 2-acetoxyimino- or 2-methoxyimino-2-aryl-ethylphosphonates, 3 or 4, by hydrogenation using Raney-Ni as a catalyst, followed by hydrolysis with HCl. 3 and 4 were obtain

ANIMATION REDUCTRICE DES β-CETOPHOSPHONATES: PREPARATION D'ACIDES AMINOALKYLPHOSPHONIQUES

Diethyl 2-oxo-alkylphosphonates undergo reductive amination in the presence of an amine and sodium cyanohydridoborate (NaBH3CN) in MeOH at Ph 7-7.5.Studies with a large variety of ketophosphonates show that the reaction rate is very sensitive to steric hi