672938-02-2

Usage

Chemical structure

Contains a benzoxazolone ring, a chloro substituent, and a tetrahydro-6-oxo-5-phenyl-3-pyridazinyl group.

Molecular weight

335.76 g/mol

Physical state

Solid

Applications

Potential use in pharmaceutical industry as a drug or intermediate in the synthesis of pharmaceuticals.

Reactivity

Depends on the exact chemical structure and requires further research and testing to determine its potential applications and effects.

Upstream product

• 26488-93-7 N-(5-chloro-2-hydroxyphenyl)acetamide 
• 672937-98-3 2-phenyl-4-(5-chloro-2-oxo-3H-benzoxazol-7-yl)-4-oxobutyronitrile 
• 672937-96-1 3-phenyl-1-(5-chloro-2-oxo-3H-benzoxazol-7-yl)-2-propen-1-one 
• 672937-95-0 7-acetyl-5-chloro-2-oxo-3H-benzoxazole 
• 100-52-7 benzaldehyde 
• 21312-94-7 2-acetylamino-6-acetyl-4-chlorophenol 

Relevant academic research and scientific papers

Investigations of new pyridazinone derivatives for the synthesis of potent analgesic and anti-inflammatory compounds with cyclooxygenase inhibitory activity

In this study we describe the synthesis of two novel 4-phenyl- and 4-(2-chlorophen-yl)-6-(5-chloro-2-oxo-3H-benzoxazol-7-yl)-3(2H)-pyridazinone derivatives (compounds 8 a and b) and their testing as inhibitors of cyclooxygenases (COX-1 and COX-2). Both compounds inhibited COX-1 (by 59% and 61% for compounds 8 a and 8 b respectively) and COX-2 (by 37% and 28% for compounds 8 a and 8 b respectively) at a concentration of 10 μM. Furthermore, we tested the analgesic and anti-inflammatory activities of the synthesized compounds in vivo by using the p-benzoquinone-induced writhing test and the carrageenan-induced hind paw edema model, respectively. Compounds 8 a and b showed potent analgesic and anti-inflammatory activities without causing gastric lesions in the tested animals.