6732-85-0

Basic information

• Product Name: 1,3,5-Trihydroxyxanthone
• Synonyms: 1,3,5-Trihydroxyxanthone;1,3,5-Trihydroxy-9H-xanthen-9-one
• CAS NO: 6732-85-0
• Molecular Formula: C₁₃H₈O₅
• Molecular Weight: 244.19962
• Mol File: 6732-85-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 525.8 °C at 760 mmHg
• Flash Point: 211.6 °C
• Appearance: /
• Density: 1.64 g/cm³
• Vapor Pressure: 1.13E-11mmHg at 25°C
• Refractive Index: 1.758
• CAS DataBase Reference: 1,3,5-Trihydroxyxanthone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5-Trihydroxyxanthone(6732-85-0)
• EPA Substance Registry System: 1,3,5-Trihydroxyxanthone(6732-85-0)

Safety Data

• Hazardous Substances Data: 6732-85-0(Hazardous Substances Data)

Usage

Definition

ChEBI: A member of the class of xanthones that is xanthone substituted by hydroxy groups at positions 1, 3 and 5. It has been isolated from Anaxagorea luzonensis.

InChI:InChI=1/C13H8O5/c14-6-4-9(16)11-10(5-6)18-13-7(12(11)17)2-1-3-8(13)15/h1-5,14-16H

Upstream product

• 83-30-7 acide 2,4,6-trihydroxybenzoique 
• 120-80-9 benzene-1,2-diol 
• 108-73-6 3,5-dihydroxyphenol 
• 877-22-5 3-methoxysalicylic acid 
• 6563-50-4 1,3,5-trimethoxy-9H-xanthen-9-one 
• 108-95-2 phenol 
• 6343-00-6 2-hydroxy-2',3,4',6'-tetramethoxybenzophenone 
• 7169-06-4 2,3-dimethoxybenzoyl chloride 
• 1521-38-6 2,3-dimethoxybenzoic acid 
• 6563-47-9 1,3-dihydroxy-5-methoxy-9H-xanthen-9-one 
• 303-38-8 2,3-Dihydroxybenzoic acid 

Downstream Products

• 20245-38-9 Rubraxanthone 
• 33390-41-9 8-deoxygartanin 
• 61243-70-7 C₂₇H₂₀O₅ 
• 26486-92-0 6-deoxyisojacareubin 
• 53377-61-0 1,3,5-trihydroxy-4-(3-methylbut-2-enyl)-9H-xanthen-9-one 

Relevant articles and documents

γ-Pyrone compounds as potential anti-cancer drugs

The γ-pyrones, artomunoxanthotrione epoxide, cyclocommunol, cyclomulberrin, and cyclocommunin exhibited potent inhibition of human PLC/PRF/5 and KB cells in-vitro. Dihydroisocycloartomunin showed significant and potent inhibition of human PLC/PRF/5 and KB

An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization

Xanthones and their thio-derivatives are a class of pleiotropic compounds with various reported pharmacological and biological activities. Although these activities are mainly determined in laboratory conditions, the class itself has a great potential to be utilized as promising chemical scaffold for the synthesis of new drug candidates. One of the main obstacles in utilization of these compounds was related to the difficulties in their chemical synthesis. Most of the known methods require two steps, and are limited to specific reagents not applicable to a large number of starting materials. In this paper a new and improved method for chemical synthesis of xanthones is presented. By applying a new procedure, we have successfully obtained these compounds with the desired regioselectivity in a shorter reaction time (50 s) and with better yield (>80%). Finally, the preliminary in vitro screenings on different bacterial species and cytotoxicity assessment, as well as in silico activity evaluation were performed. The obtained results confirm potential pharmacological use of this class of molecules.

Identification of Xanthones as Selective Killers of Cancer Cells Overexpressing the ABC Transporter MRP1

Multidrug-resistance protein1 (MRP1) belongs to the ATP-binding cassette (ABC) transporter family. MRP1 mediates MDR (multidrug resistance) by causing drug efflux either by conjugation to glutathione (GSH) or by co-transport with free GSH (without covalen