67334-34-3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 143-08-8 nonyl alcohol 

Downstream Products

• 1222401-52-6 C₇H₇O₃S^(1-)*C₃₆H₆₇N₂O₂S⁽¹⁺⁾ 
• 59812-98-5 tridecan-2-ol 
• 1653-31-2 (S)-(+)-tridecan-2-ol 
• 657403-19-5 [Pd(O-p-toluenesulfonyl)(n-nonyl)(P(tert-butyl)2(methyl))2] 
• 103009-91-2 (All-E)-9-[2-(nonyloxy)phenyl]-3,7-dimethyl-2,4,6,8-nonatetraenoic acid 

Relevant academic research and scientific papers

Synthesis of Long Alkyl Chain Mono- and Di-N-substituted 4-Amino-N-methylphthalimides. Comparison of N-Alkylation Methods

4-Amino-N-methylphthalimide, 1, was N-alkylated with the respective n-alkyl sulfonates and halides.In the former case, the di-derivative 4 was favored, while in the latter case, under phase transfer catalysis, the mono-derivative 3 was predominant.

Synthesis of structural analogues of hexadecylphosphocholine and their antineoplastic, antimicrobial and amoebicidal activity

Twelve derivatives of hexadecylphosphocholine (miltefosine) were synthesized to determine how the position and length of the alkyl chain within the molecule influence their biological activities. The prepared alkylphosphocholines have the same molecular formula as miltefosine. Activity of the compounds was studied against a spectrum of tumour cells, two species of protozoans, bacteria and yeast. Antitumour efficacy of some alkylphosphocholines measured up on MCF-7, A2780, HUT-78 and THP-1 cell lines was higher than that of miltefosine. The compounds showed antiprotozoal activity against Acanthamoeba lugdunensis and Acanthamoeba quina. Some of them also possess fungicidal activity against Candida albicans equal to miltefosine. No antibacterial activity was observed against Staphylococcus aureus and Escherichia coli. A difference in position of a long hydrocarbon chain within the structure with maximum efficacy was observed for antitumour, antiprotozoal and antifungal activity.

Amphiphilic organocatalyst for schotten-baumann-type tosylation of alcohols under organic solvent free condition

A Tosylation of primary alcohol with tosyl chloride was performed effectively with an W-hexadecylimidazole catalyst in water containing K 2CO3 aggregation of the catalyst carrying a hydrophobic methylene chain worked as a substitute for organic solvent.

Process for preparation of oxyglutaric acid ester derivatives

A process for preparing an oxyglutaric acid ester derivative of the formula: STR1 in which each of R1 and R2 is C1-5 alkoxy, C1-7 aralkyloxy, C7-9 halogenated aralkyloxy or phenyl, R4 is a hydroxyl-protecting group, and R5 is C1-10 alkyl which may have a substituent, comprises the steps of reacting a methyl phosphonate derivative or methyl phosphine oxide derivative with an oxyglutaric acid mono-ester to give a reaction product which comprises an oxyglutaric acid derivative having a phosphorus-containing group and a pentenedioic acid mono-ester (by-product), removing the pendenedioic acid mono-ester from the reaction product to isolate the oxyglutaric acid derivative, and converting the isolated oxyglutaric acid derivative into the oxyglutaric acid ester derivative. A process for obtaining an optically active oxyglutaric acid ester derivative is also disclosed.