76600-38-9

Basic information

• Product Name: A20668
• Synonyms: A20668;Tryanocidin, CC 1014, M 13959, ML 1014, P 168, SF 1907VIII, U 53496
• CAS NO: 76600-38-9
• Molecular Formula: C₆₂H₁₁₁N₁₁O₁₃
• Molecular Weight: 1218.6106
• Mol File: 76600-38-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1408°C at 760 mmHg
• Flash Point: 805.3°C
• Appearance: /
• Density: 1.116g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.515
• PKA: 12.66±0.46(Predicted)
• CAS DataBase Reference: A20668(CAS DataBase Reference)
• NIST Chemistry Reference: A20668(76600-38-9)
• EPA Substance Registry System: A20668(76600-38-9)

Safety Data

• Hazardous Substances Data: 76600-38-9(Hazardous Substances Data)

Usage

Description

Leucinostatin A is a fungal metabolite originally isolated from P. lilacinus with diverse biological activities. It is active against P. oryzae, B. cinera, P. chrysogenum, X. oryzae, S. cerevisiae, and C. albicans fungi and B. subtilis, S. aureus, S. lutea, and M. phlei bacteria in a disc assay. Leucinostatin A (0.1-1 μg/ml) reduces T cell activation induced by phorbol 12-myristate 13-acetate (TPA; ) or an anti-CD3 antibody in a concentration-dependent manner. It inhibits proliferation of DU145 prostate cancer cells co-cultured with PrSC stromal cells in vitro (IC50 = 0.045 μg/ml).

Uses

Different sources of media describe the Uses of 76600-38-9 differently. You can refer to the following data:
1. Leucinostatin A is the major component of an atypical nonapeptide complex produced by Paecilomyces lilacinus, first reported in 1973. Leucinostatins display broad bioactivity against Gram positive bacteria, fungi, plants and tumour cell lines. Leucinostatin A inhibits respiration by uncoupling oxidative phosphorylation and is potentiated by inhibitors such as venturicidin and oligomycin. More recently, interest in leucinostatin has focused on understanding its activity as an insulin-like growth factor I regulator, an ionophore, inhibitor of cell surface expression of viral glycoproteins and its anti-trypanosomal activity.
2. Leucinostatin A is a broadly bioactive component produced by?Paecilomyces lilacinus..

InChI:InChI=1/C62H111N11O13/c1-21-38(9)23-24-49(77)73-33-40(11)31-47(73)55(82)66-46(30-39(10)29-43(75)32-42(74)22-2)53(80)68-50(51(78)37(7)8)56(83)70-61(15,16)58(85)67-44(27-35(3)4)52(79)65-45(28-36(5)6)54(81)69-62(17,18)59(86)71-60(13,14)57(84)63-26-25-48(76)64-41(12)34-72(19)20/h23-24,35-41,43-47,50-51,75,78H,21-22,25-34H2,1-20H3,(H,63,84)(H,64,76)(H,65,79)(H,66,82)(H,67,85)(H,68,80)(H,69,81)(H,70,83)(H,71,86)/b24-23+

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