6734-79-8

Basic information

• Product Name: (4R)-1-Methyl-4-propyl-L-proline Hydrochloride
• Synonyms: (4R)-1-Methyl-4-propyl-L-proline Hydrochloride;1-Methyl-4-propyl-L-trans-proline Hydrochloride;4-n-Propyl Hygric Acid Hydrochloride;L-trans-1-Methyl-4-propyl-proline Hydrochloride;trans-Propylhygric Acid Hydrochloride;Lincomycin hydrochloride impurity E
• CAS NO: 6734-79-8
• Molecular Formula: C₉H₁₇NO₂*ClH
• Molecular Weight: 207.69772
• Product Categories: Amino Acids & Derivatives;Chiral Reagents;Heterocycles
• Mol File: 6734-79-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Methanol (Slightly), Water (Slightly, Sonicated)
• CAS DataBase Reference: (4R)-1-Methyl-4-propyl-L-proline Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-1-Methyl-4-propyl-L-proline Hydrochloride(6734-79-8)
• EPA Substance Registry System: (4R)-1-Methyl-4-propyl-L-proline Hydrochloride(6734-79-8)

Safety Data

• Hazardous Substances Data: 6734-79-8(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Solid

Upstream product

• 50-00-0 formaldehyd 
• 161881-09-0 2-(bromomethyl)pent-1-ene 
• 13380-37-5 (2S,4R)-1-Methyl-4-propyl-pyrrolidine-2-carboxylic acid hydrazide 

Downstream Products

• 1146963-00-9 methyl 1,4,5,6,9-penta-O-benzyl-8,10-dideoxy-8-[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxamido]-3-thio-D-ribo-β-L-gluco-dec-3-ulopyranoside 
• 1146962-98-2 methyl 2-O-acetyl-1,4,5,6,9-penta-O-benzyl-8,10-dideoxy-8-[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxamido]-3-thio-D-ribo-β-L-manno-dec-3-ulopyranoside 
• 1146962-68-6 methyl 5,6,7,10-tetra-O-benzyl-2,3,9,11-tetradeoxy-9-[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxamido]-4-thio-D-erythro-α-D-galacto-undec-4-ulopyranosidonitrile 
• 1146962-71-1 methyl {methyl 5,6,7,10-tetra-O-benzyl-2,3,9,11-tetradeoxy-9-[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxamido]-4-thio-D-erythro-α-D-galacto-undec-4-ulopyranosid}onate 
• 1146962-44-8 phenyl 2,3,4,7-tetrakis-O-[(tert-butyl)dimethylsilyl]-6,8-dideoxy-6-[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxamido]-1-thio-D-erythro-α-D-galacto-octopyranoside 
• 1146962-45-9 4-chlorophenyl 2,3,4,7-tetrakis-O-[(tert-butyl)dimethylsilyl]-6,8-dideoxy-6-[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxamido]-1-thio-D-erythro-α-D-galacto-octopyranoside 
• 1146962-46-0 4-methoxyphenyl 2,3,4,7-tetrakis-O-[(tert-butyl)dimethylsilyl]-6,8-dideoxy-6-[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxamido]-1-thio-D-erythro-α-D-galacto-octopyranoside 
• 1146962-58-4 methyl 1-O-acetyl-3,4,5,8-tetra-O-benzyl-7,9-dideoxy-7-[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxamido]-2-thio-D-erythro-α-D-galacto-non-2-ulopyranoside 
• 1146962-89-1 methyl (1R)-1-O-acetyl-3,4,5,8-tetra-O-benzyl-7,9-dideoxy-1-C-heptyl-7-[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxamido]-2-thio-D-erythro-α-D-galacto-non-2-ulopyranoside 
• 1146962-87-9 methyl (1S)-1-O-acetyl-3,4,5,8-tetra-O-benzyl-7,9-dideoxy-1-C-heptyl-7-[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxamido]-2-thio-D-erythro-α-D-galacto-non-2-ulopyranoside 
• 13380-39-7 methyl (2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxylate 
• 148077-13-8 lincophenicol 

Relevant articles and documents

Stereocontrol in the synthesis of cyclic amino acids: a new ligand for directed hydrogenation through hydrogen bonding

A system for the directed hydrogenation of nitrogen heterocycles is described in which hydrogen is delivered cis to a hydroxymethyl group by a rhodium catalyst with a simple phosphine ligand. The chemistry is applied to the synthesis of the hygric acid moiety of lincomycin and the pipecolic acid moiety of Argatroban. A series of control experiments indicate that the stereoselectivity is a result of a combination of both coordination and hydrogen bonding.