673479-02-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 673478-86-9 5'-O-(4,4'-dimethoxytrityl)-3'-hydroxymethyl-2'-deoxy-D-ribonolactone 
• 252667-55-3 (S)-5-(4,4'-dimethoxytrityloxymethyl)-5H-furan-2-one 
• 78508-96-0 (5S)-5-(hydroxymethyl)-5H-furan-2-one 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 673479-04-4 Acetic acid (4R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl ester 
• 673479-03-3 (4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-ol 

Relevant academic research and scientific papers

Synthetic studies towards a novel, chemical stable, abasic site analogue of DNA

We synthesized the phosphinate 7 via photoaddition of methanol to the α,β unsaturated deoxyribono lactone as the key step, followed by an Arbusov reaction for the introduction of phosphorous. Precursor 7 serves for the synthesis and incorporation into DNA