673478-86-9

Upstream product

• 78508-96-0 (5S)-5-(hydroxymethyl)-5H-furan-2-one 
• 34371-14-7 2-deoxy-D-ribonolactone 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 869494-51-9 5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-D-ribonolactone 
• 67-56-1 methanol 
• 252667-55-3 (S)-5-(4,4'-dimethoxytrityloxymethyl)-5H-furan-2-one 

Downstream Products

• 673479-02-2 (4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-dihydro-furan-2-one 
• 673479-04-4 Acetic acid (4R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl ester 
• 673478-92-7 {(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-iodomethyl-tetrahydro-furan-2-yloxy}-tert-butyl-dimethyl-silane 
• 673479-03-3 (4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-ol 
• 673478-91-6 Acetic acid (2R,4S,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-iodomethyl-tetrahydro-furan-2-yl ester 
• 673478-97-2 (2S,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-iodomethyl-tetrahydro-furan-2-ol 
• 869494-52-0 5'-O-(4,4'-dimethoxytrityl)-3'-iodomethyl-2'-deoxy-1'-O-acetyl-D-ribose 
• 673478-88-1 5'-O-(4,4'-dimethoxytrityl)-3'-iodomethyl-2'-deoxy-D-ribonolactone 
• 673478-98-3 Trifluoro-methanesulfonic acid (2S,3R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-oxo-tetrahydro-furan-3-ylmethyl ester 

Relevant academic research and scientific papers

Synthesis and incorporation into DNA of a chemically stable, functional abasic site analogue

(Chemical Equation Presented) The abasic site building block 7 for DNA synthesis, containing a methylenephosphinic acid group at C3′, was prepared in six steps and was incorporated into DNA via a combination of H-phosphonate and phosphoramidite chemistry.

Synthetic studies towards a novel, chemical stable, abasic site analogue of DNA

We synthesized the phosphinate 7 via photoaddition of methanol to the α,β unsaturated deoxyribono lactone as the key step, followed by an Arbusov reaction for the introduction of phosphorous. Precursor 7 serves for the synthesis and incorporation into DNA