252667-55-3Relevant academic research and scientific papers
Synthesis and incorporation into DNA of a chemically stable, functional abasic site analogue
Mosimann, Markus,Kuepfer, Pascal A.,Leumann, Christian J.
, p. 5211 - 5214 (2007/10/03)
(Chemical Equation Presented) The abasic site building block 7 for DNA synthesis, containing a methylenephosphinic acid group at C3′, was prepared in six steps and was incorporated into DNA via a combination of H-phosphonate and phosphoramidite chemistry.
Synthetic studies towards a novel, chemical stable, abasic site analogue of DNA
Hirtz, Caroline,Leumann, Christian J.
, p. 1203 - 1206 (2007/10/03)
We synthesized the phosphinate 7 via photoaddition of methanol to the α,β unsaturated deoxyribono lactone as the key step, followed by an Arbusov reaction for the introduction of phosphorous. Precursor 7 serves for the synthesis and incorporation into DNA
