67359-63-1Relevant articles and documents
A 2 - (4,6-dimethyl-pyrimidin-2-yl-carbamoyl amino sulfonyl) benzoic acid synthesis of methyl
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Paragraph 0043; 0057; 0058, (2016/10/07)
The invention discloses a synthetic method of 2-(4, 6-dimethyl pyrimidine-2-base amino formyl amino sulfonyl) methyl benzoate. The method is characterized in that gluside and dimethyl carbonate are adopted for preparing an intermediate of N-methyl formate-o-sulfonylbenzoylimine, and then methanol is adopted for preparing an intermediate of o-methoxy carboxide benzenesulfonamide methyl formate. The purity of 2-(4,6-dimethyl pyrimidine-2-base amino formyl amino sulfonyl) methyl benzoate prepared by the synthetic method provided by the invention reaches more than 95.0%, and the total yield reaches 55.0%. The method is mainly applied to preparation of 2-(4, 6-dimethyl pyrimidine-2-base amino formyl amino sulfonyl) methyl benzoate and has the advantages that raw materials are cheap and easy to obtain, the technology is simple, the three wastes are few, virulent suffocating gas is prevented from being used, and the method is suitable for batch industrialized production.