6736-58-9 Usage
Uses
Used in Pharmaceutical Industry:
3-Deazaadenosine is used as an anti-inflammatory agent for its ability to inhibit leukocyte adhesion and various immune response pathways. This property makes it a promising candidate for the development of drugs targeting inflammatory conditions.
Used in Antiviral Applications:
3-Deazaadenosine is used as an antiviral agent due to its ability to inhibit viral replication and spread. Its antiviral activity can be harnessed in the development of new therapeutics to combat viral infections.
Used in Antibacterial Applications:
3-Deazaadenosine is used as an antibacterial agent, leveraging its ability to inhibit bacterial growth and proliferation. This characteristic can be utilized in the development of novel antibiotics to address bacterial infections.
Used in Research and Development:
3-Deazaadenosine is used as a research tool for studying the mechanisms of leukocyte adhesion, immune response, and microbial infections. Its multifaceted activities make it a valuable compound for understanding various biological processes and developing targeted therapies.
Biochem/physiol Actions
Possesses antiviral activity inhibitor of leukocyte adhesion to TNF-treated endothelial cells.
in vitro
3-deazaadenosine showed inhibitory values against the ebo-z viruses, ebo, and marburg virus in various cell lines of primate (sw13, vero 76, frhl, llc-mk2, mrc-5, vero e6) and mouse (balb/3t3 clone a31) origin. 3-deazaadenosine at 2 μg/ml could reduce viral replication by 3 logs in a dose-dependent manner. however, there was no further inhibition even with a 100-fold increase in concentration [1].
in vivo
in vehicle control group, adult balb/c mice lethally infected with mouse-adapted ebola virus die 5-7 days after infection. in contrast, 3-deazaadenosine treatment initiated on day 0 or 1 led to a dose-dependent protection, with mortality completely prevented at doses around 0.7 mg/kg every 8 h. moreover, there was significant protection when 3-deazaadenosine treatment was begun on day 2, at which time, the spleen had an average titer of 2 × 106 pfu/g and the liver had 3 × 105 pfu/g virus. treatment with 3-aeazaadenosine at 2.2 mg/kg initiated on day 3 resulted in 40% survival [1].
references
[1] huggins, z. x. zhang and m. bray. antiretroviral drug therapy of filovirus infections: s-adenosylhomocysteine hydrolase inhibitors inhibit ebola virus in vitro and in a lethal mouse model. journal of infectious diseases 179 (1), s240-s247 (1999).
Check Digit Verification of cas no
The CAS Registry Mumber 6736-58-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,7,3 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6736-58:
(6*6)+(5*7)+(4*3)+(3*6)+(2*5)+(1*8)=119
119 % 10 = 9
So 6736-58-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H14N4O4/c12-10-7-5(1-2-13-10)15(4-14-7)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
