886227-24-3

Upstream product

• 300853-86-5 5-amino-1-[2',3',5'-O-tris(tert-butyldimethylsilyl)-β-D-ribofuranosyl]imidazole-4-carboxamide 
• 58-63-9 Inosine 
• 6736-58-9 3-deazaadenosine 
• 147212-86-0 4-amino-1-(2,3,5-tri-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)imidazo<4,5-c>pyridine 
• 110526-62-0 2',3',5'-tris-O-(tert-butyldimethylsilyl)-2'-deoxyinosine 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 886227-18-5 2',3',5'-O-tris(tert-butyldimethylsilyl)-1-(2,4-dinitrophenyl)inosine 
• 886227-19-6 5-amino-1-[2',3',5'-O-tris(tert-butyldimethylsilyl)-β-D-ribofuranosyl]imidazole-4-carbonitrile 
• 886227-20-9 5-iodo-1-[2',3',5'-O-tris(tert-butyldimethylsilyl)-β-D-ribofuranosyl]imidazole-4-carbonitrile 
• 886227-23-2 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-3-deazaadenosine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 666257-76-7 2'-deoxy-3'-O-[(N,N-diisopropylamino)-(β-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)-N⁶-benzoyl-3-deazaadenosine 
• 143556-17-6 5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-N⁶-benzoyl-3-deazaadenosine 
• 886227-26-5 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxy-N⁶-benzoyl-3-deazaadenosine 
• 143354-17-0 2'-deoxy-N⁶-benzoyl-3-deazaadenosine 

Relevant academic research and scientific papers

Efficient ribosomal peptidyl transfer critically relies on the presence of the ribose 2′-OH at A2451 of 23S rRNA

The ribosomal peptidyl transferase center is a ribozyme catalyzing peptide bond synthesis in all organisms. We applied a novel modified nucleoside interference approach to identify functional groups at 9 universally conserved active site residues. Owing t