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Methyl 4-hydroxynicotinate is a white powder chemical compound that serves as a crucial reagent in the synthesis of various compounds, particularly Trigonelline, an alkaloid found in coffee and fenugreek with phytoestrogenic activity.

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  • 67367-24-2 Structure
  • Basic information

    1. Product Name: Methyl 4-hydroxynicotinate
    2. Synonyms: 4-HYDROXYPYRIDINE-3-CARBOXYLIC ACID METHYL ESTER;4-HYDROXY-NICOTINIC ACID METHYL ESTER;3-Pyridinecarboxylicacid,4-hydroxy-,methylester(9CI);Methyl 4-hydroxynicotinate;Methyl 4-hydroxypyridine-3-carboxylate
    3. CAS NO:67367-24-2
    4. Molecular Formula: C7H7NO3
    5. Molecular Weight: 153.14
    6. EINECS: 604-604-1
    7. Product Categories: CARBOXYLICESTER;blocks;Carboxes;Pyridines;pharmacetical
    8. Mol File: 67367-24-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 272.9 °C at 760 mmHg
    3. Flash Point: 118.8 °C
    4. Appearance: /
    5. Density: 1.263g/cm3
    6. Vapor Pressure: 0.00593mmHg at 25°C
    7. Refractive Index: 1.517
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    9. Solubility: N/A
    10. PKA: 8.18±0.10(Predicted)
    11. CAS DataBase Reference: Methyl 4-hydroxynicotinate(CAS DataBase Reference)
    12. NIST Chemistry Reference: Methyl 4-hydroxynicotinate(67367-24-2)
    13. EPA Substance Registry System: Methyl 4-hydroxynicotinate(67367-24-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 67367-24-2(Hazardous Substances Data)

67367-24-2 Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-hydroxynicotinate is used as a reagent for the synthesis of Trigonelline (T794000), an alkaloid with potential applications in the development of pharmaceutical products due to its phytoestrogenic activity. This activity may contribute to the regulation of hormonal balance and could be beneficial in the treatment of conditions related to hormonal imbalances.
Used in Chemical Synthesis:
As a white powder chemical compound, Methyl 4-hydroxynicotinate is also utilized in various chemical synthesis processes, where it can act as an intermediate or a building block for the creation of other complex molecules with diverse applications in different industries.

Check Digit Verification of cas no

The CAS Registry Mumber 67367-24-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,3,6 and 7 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 67367-24:
(7*6)+(6*7)+(5*3)+(4*6)+(3*7)+(2*2)+(1*4)=152
152 % 10 = 2
So 67367-24-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H7NO3/c1-11-7(10)5-4-8-3-2-6(5)9/h2-4H,1H3,(H,8,9)

67367-24-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 4-hydroxynicotinate

1.2 Other means of identification

Product number -
Other names Methyl 4-hydroxypyridine-3-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:67367-24-2 SDS

67367-24-2Downstream Products

67367-24-2Relevant articles and documents

Monoacylglycerol Lipase Modulators

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Paragraph 0410; 0624, (2020/04/24)

Bridged compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. wherein R2, R3 R4, R5 and R6 are defined herein.

MODIFIED COMPOUND OF ANDROGRAPHOLIDE

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Paragraph 0214-0216, (2019/01/04)

The present disclosure discloses a modified compound of andrographolide, and particularly discloses a compound shown in formula (I) and (II) or a pharmaceutically acceptable salt thereof.

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