67370-67-6Relevant academic research and scientific papers
Copper-Catalyzed Amide Radical-Directed Cyanation of Unactivated Csp3-H Bonds
Zhang, Hongwei,Zhou, Yulu,Tian, Peiyuan,Jiang, Cuiyu
supporting information, (2019/03/19)
A method for site-selective intermolecular δ/?-Csp3-H cyanation of aliphatic sulfonamides is developed using TsCN as the cyanating reagent, catalyzed by a Cu(I)/phenanthroline complex. The mild, expeditious, and modular protocol allows efficient remote Csp3-H cyanation with good functional group tolerance and high regioselectivity. Mechanistic studies indicate that the reaction might proceed through a Cu(I)-mediated N-F bond cleavage to generate an amidyl radical, 1,5-HAT, and cyano group transfer of the resulting carbon radical with TsCN.
Synthesis of Macrotricyclic Amines
Schmidtchen, Franz P.
, p. 864 - 874 (2007/10/02)
The synthesis of the macrotricyclic amines 14a and b with a tetrahedron skeleton is achieved by three successive cyclisations using high dilution conditions (overall yields 5.6 and 2.5percent, resp.).
