67413-26-7

Usage

Uses

Used in Pharmaceutical Industry:
(S)-2-Aziridinecarboxylic acid benzyl ester is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, (S)-2-Aziridinecarboxylic acid benzyl ester is used as a precursor in the production of various agrochemicals. Its versatility in organic synthesis allows for the creation of compounds that can be used in pest control, crop protection, and other agricultural applications.
Used in Organic Synthesis:
(S)-2-Aziridinecarboxylic acid benzyl ester is used as a reagent in organic synthesis for the preparation of diverse chemical compounds. Its unique properties and reactivity contribute to the synthesis of a wide range of organic compounds, making it an important tool in the field of chemistry.

Upstream product

• 1738-72-3 L-serine benzyl ester 
• 67413-25-6 benzyl (-)-(2S)-1-trityl-aziridine-2-carboxylate 
• 104597-98-0 (S)-2-methoxycarbonyl-1-benzyloxycarbonylaziridine 
• 100-51-6 benzyl alcohol 
• 153381-07-8 (S)-N-methoxycarbonyl aziridine-2-carboxylatemethyl ester 
• 100-39-0 benzyl bromide 
• 67553-36-0 benzyl 3-hydroxy-2-(tritylamino)propanoate 
• 86852-11-1 diethoxyltriphenylphosphorane 

Downstream Products

• 86961-11-7 benzyl (S)-N-carbethoxyaziridinecarboxaldehyde 
• 84437-84-3 Z-Ala-Azy-OBzl 
• 131353-64-5 benzyl N-(N-(tert-butyloxycarbonyl)phenylalanyl)-L-aziridine-2-carboxylate 
• 83824-80-0 benzyl (2S)-1-benzyloxycarbonyl-aziridine-2-carboxylate 
• 86961-12-8 (2R)-O-benzyl N-carbethoxy-S-(2-carbethoxy-n-propyl)-L-cysteine 
• 86961-13-9 (R)-2-Ethoxycarbonylamino-3-((S)-2-methoxycarbonyl-propylsulfanyl)-propionic acid benzyl ester 
• 719307-84-3 2-benzyl 1-tert-butyl (2S)-aziridine-1,2-dicarboxylate 
• 83824-85-5 (S)-2-Benzyloxycarbonylamino-3-cyclohexyloxy-propionic acid benzyl ester 
• 83824-86-6 (S)-3-Benzyloxy-2-benzyloxycarbonylamino-propionic acid benzyl ester 
• 20700-93-0 Z-Ser(O-t-Bu)-OBn 
• 83824-83-3 (S)-2-Benzyloxycarbonylamino-3-isopropoxy-propionic acid benzyl ester 
• 126908-69-8 Z-Ala-Ser(Bz)-OBzl 

Relevant academic research and scientific papers

COVALENT RAS INHIBITORS AND USES THEREOF

The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.

RAS INHIBITORS

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

Selective cleavage of carbamate protecting groups from aziridines with otera's catalyst

Otera's distannoxane catalyst was found to promote the cleavage of carbamate groups from N-protected aziridines. This method enables the chemoselective cleavage of an aziridinyl N-carbobenzyloxy (Cbz) group in the presence of other N-Cbz groups. The selec

On The Synthesis of (2S)-Aziridine-2-Carboxylic Acid Containing Peptides

Optimized conditions are described for the synthesis of 1-trityl-2-aziridine-carboxylic acid 3 (Trt-Azy-OH) and benzyl (2S)-aziridine-2-carboxylate 6 (H-Azy-OBzl) as useful derivatives for the synthesis of N- and C-terminal aziridine-containing peptides.Thereby, the use of the pentafluorophenyl ester of Trt-Azy-OH was found to be the method of choice in acylating steps, whereas acylation of H-Azy-OBzl several classical methods of peptide synthesis can be succesfully used.The fully protected aziridine-2-carboxylic acid peptides are accessible in satisfactory yields as analytically defined products, but partial or total deprotection of these compounds again by standard procedures of peptide synthesis is surprisingly difficult in terms of satisfactory yields, whereby sequence-dependent unstability both in the reaction and purification steps as well as on storage was found to strongly limit the accessibility of these aziridine-containing peptides as promising active-site inactivators of cysteine-proteinases.

An expeditious in situ preparation of benzyl (S)-2-aziridinecarboxylate

The use of diethoxytriphenylphosphorane in the preparation of benzyl (S)-2-aziridinecarboxylate is illustrated.The latter compound has been coupled with Z-Ala-OH and the aziridine dipeptide thus obtained ring-opened via C-3-N-1 cleavage with benzyl alcoho

PREPARATION AND PROPERTIES OF S,S-DIPHENYL AMINO ACID PHOSPHORODITHIOATES

S,S-diphenyl phosphorodithioates of appropriately protected serine and tyrosine have been prepared.In the case of serine, neighbouring group participation of a free N- or C-terminus on the corresponding triester functions leads to the formation of aziridi