67428-06-2

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 132587-07-6 1-phenylbut-3-enyl acetate 
• 100-52-7 benzaldehyde 
• 14371-10-9 (E)-3-phenylpropenal 
• 16939-57-4 (E)-buta-1,3-dienylbenzene 
• 31915-94-3 (Z)-1-Phenylbuta-1,3-diene 
• 140-10-3 (E)-3-phenylacrylic acid 
• 6286-30-2 2,3-dibromo-3-phenylpropanoic acid 
• 588-73-8 (Z)-β-bromostyrene 

Downstream Products

• 106730-35-2 2-((E)-Styryl)-cyclopropanecarbonyl chloride 
• 106730-41-0 (1S,2S)-2-Phenyl-cyclopent-3-enecarboxylic acid methyl ester 
• 106730-41-0 (1R,2S)-2-Phenyl-cyclopent-3-enecarboxylic acid methyl ester 
• 35008-85-6 (1E,3E,5E)-octa-1,3,5,7-tetraen-1-ylbenzene 
• 3864-19-5 ((1E,3E)-hexa-1,3,5-trien-1-yl)benzene 
• 39918-80-4 (E)-2-styrylcyclopropanecarboxylic acid 

Relevant academic research and scientific papers

LSD1 INHIBITORS AND USES THEREOF

Provided are novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSDl. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSDl.

LEWIS ACID CATALYZED REARRANGEMENT OF VINYLCYCLOPROPANECARBONYL CHLORIDE TO CYCLOPENTENECARBONYL CHLORIDE

Vinylcyclopropane-cyclopentene rearrangement of 2-(2-aryl-vinyl) cyclopropanecarbonyl chlorides was observed upon treatment with a Lewis acid under mild reaction conditions to afford 2-arylcyclopent-3-enecarboxylates after esterification.

REGIOSELECTIVITY IN CATALYTIC CYCLOPROPANATION REACTIONS

Regioselectivities of cyclopropanation reactions with ethyl diazoacetate and monosubstituted dienes correlate linearly with the reaction catalyst and provide definition of the "metal carbene regioselectivity index".