67434-29-1

Usage

InChI:InChI=1/C7H10N2O2/c1-8-6-7(10)9-2-4-11-5-3-9/h2-6H2

Upstream product

• 110-91-8 morpholine 
• 39687-95-1 isocyanoacetic acid methyl ester 
• 2999-46-4 Ethyl isocyanoacetate 

Downstream Products

• 63348-64-1 4-(2-benzyl-2-isocyano-3-phenyl-propionyl)-morpholine 
• 89205-19-6 4-morpholinocarbonyl-5-(3,4,5-trimethoxyphenyl)oxazole 
• 99506-29-3 α-formylaminocyclopentylideneacetylmorpholine 
• 608525-89-9 4-[2-(1-trimethylsilanyloxy-cyclohexyl)-oxazol-5-yl]-morpholine 
• 608525-90-2 4-[2-(1-triethylsilanyloxy-cyclohexyl)-oxazol-5-yl]-morpholine 
• 651021-97-5 6-benzyl-7-hexyl-2-morpholin-4-yl-4,5,6,7-tetrahydro-furo[2,3-c]pyridine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Silver-Catalyzed Acyl Nitrene Transfer Reactions Involving Dioxazolones: Direct Assembly of N-Acylureas

Dioxazolones and isocyanides are useful synthetic building blocks, and have attracted significant attention from researchers. However, the silver-catalyzed nitrene transfer reaction of dioxazolones has not been investigated to date. Herein, a silver-catalyzed acyl nitrene transfer reaction involving dioxazolones, isocyanides, and water was realized in the presence of Ag2O to afford a series of N-acylureas in moderate to good yields.

Silver-Catalyzed Chemoselective [4+2] Annulation of Two Isocyanides: A General Route to Pyridone-Fused Carbo- and Heterocycles

A silver-catalyzed chemoselective [4+2] annulation of aryl and heteroaryl isocyanides with α-substituted isocyanoacetamides was developed for the facile and efficient synthesis of 2-aminoquinolones, naphthyridines, and phenanthrolines. A mechanism for this multistep domino reaction is proposed on the basis of a13C-labeling experiment, according to which an unprecedented chemoselective heterodimerization of two different isocyanides generates an α-amidoketenimine intermediate, which undergoes 1,3-amino migration to form an α-imidoylketene, followed by 6 π electrocyclization.

Easy Synthesis of Two Positional Isomeric Tetrazole Libraries

A fast and efficient synthesis of libraries of positional isomeric 1H-tetrazoles and 5H-tetrazoles, for the purpose of testing binding hypothesis of isomeric tetrazoles in fragment-based drug discovery, is described.

Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones

An expeditious multicomponent reaction to synthesize tetrasubstituted furo[2,3-d]pyridazin-4(5H)-ones is reported. In brief, hydrazonoyl chlorides react with isocyanoacetamides, in the presence of TEA, to give 1,3-oxazol-2-hydrazones which, without being isolated, can react with dimethylacetylene dicarboxylate to afford furo[2,3-d]pyridazin-4(5H)-ones with an unprecedented level of complexity in a triple domino Diels-Alder/retro-Diels-Alder/lactamization reaction sequence.

Synthesis of 1,2,4-triazolines: Base-catalyzed hydrazination/cyclization cascade of α-isocyano esters and amides

A convenient, efficient synthesis of 1,2,4-triazolines from α-isocyano esters/amides and azodicarboxylates is presented. The developed reaction cascade is based on a base-catalyzed hydrazination-type reaction followed by a subsequent cyclization providing

3-(4-FLUOROPHENYL)-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS HAVING ANALGESIC ACTIVITY

Compounds according to the formula below are disclosed herein: Therapeutic methods for the treatment of pain, compositions, and medicaments related thereto are also disclosed.

METHODS FOR TREATING CHRONIC PAIN USING 3-ARYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES, 3-HETEROARYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from one or more types of chronic pain using compounds of Formulas 1 and 2 wherein the variables have the meaning disclosed in the specification

Mono alkylation of α-isocyano acetamide to its higher homologues

Alkylation of α-isocyano acetamide (2) with alkyl halide in MeCN at 0 °C in the presence of cesium hydroxide afforded the mono-alkylated product 1 in good to excellent yield. Georg Thieme Verlag Stuttgart.

Synthesis and Herbicidal Activities of &α-Isocyanocycloalkylideneacetamides

Various α-isocyanocycloalkylideneacetamides were synthetised by the reaction of isocyanoacetamides with ketones following by dehydration.These compounds were examined for their inhibitory activity against the germination of rice, cucumber and radish seeds