7138-58-1

Upstream product

• 123-38-6 propionaldehyde 
• 62-53-3 aniline 
• 71-23-8 propan-1-ol 
• 98-95-3 nitrobenzene 
• 620-71-3 N-(phenyl)-2-methylacetamide 
• 31144-24-8 N-Phenylpropionimidoyl chloride 
• 589-09-3 N-allyl-N-phenylamine 

Downstream Products

• 88091-04-7 2,5-Dimethyl-1-phenyl-1H-pyridin-4-one 
• 67467-96-3 2-methyl-3-(4-(tert-pentyl)phenyl)propanal 
• 55240-30-7 N-n-propyl-N-phenyl carbamoyl chloride 
• 1312718-55-0 C₁₇H₂₄N₂O₂ 
• 622-80-0 N-propylaniline 
• 124687-82-7 Phenyl-[(S)-1-((R)-toluene-4-sulfinylmethyl)-propyl]-amine 
• 124687-83-8 Phenyl-[(R)-1-((R)-toluene-4-sulfinylmethyl)-propyl]-amine 
• 124687-84-9 [(S)-1-((R)-Benzenesulfinylmethyl)-propyl]-phenyl-amine 
• 124687-92-9 [(R)-1-((R)-Benzenesulfinylmethyl)-propyl]-phenyl-amine 

Relevant academic research and scientific papers

Kinetic and equilibrium studies of anilinoalkanesulfonate formation

1H NMR studies of the reactions of some hydroxyalkanesulfonates, 1, with aniline derivatives, 2, show the formation at equilibrium of anilinoalkanesulfonates, 3. Kinetic studies in water are consistent with a mechanism involving dissociation of

Synthesis method of 2-methyl-3-(4-tert-amylphenyl) propanol

The invention discloses a synthesis method of 2-methyl-3-(4-tert-amylphenyl) propanol, which specifically comprises the following steps: 1, reacting propionaldehyde with primary amine R1-NH2 in the presence of a dehydrating agent to generate a compound A;

NCP ligand, [...] complex, synthesis method, intermediate and application

The invention discloses an NCP ligand, iridium complex, synthetic method, intermediate and application thereof. The invention provides an NCP ligand and an NCP ligand iridium complex, wherein R1, R2, R3, R4, R5, R6 and R7 separately represent hydrogen atom or C1-C30 alkyl, R' and R'' independently represent C1-C30 alkyl. The invention provides the application of the NCP ligand iridium complex to the catalysis of alkane dehydrogenation reaction, olefin isomerization reaction, alcohol dehydrogenation reaction, ester alpha alkylation reaction, and amide alpha alkylation reaction. The NCP ligand provided by the invention contains dialkyl substituted phosphine, which has strong electron donating ability and can form a NCP ligand iridium complex by complexing with iridium. The NCP ligand iridium complex uses pyridine to replace a conventional alkyl phosphate electron donor, and has the advantages of good stability, high selectivity on alkane dehydrogenation reaction, mild reaction conditions, good catalytic effect, and industrial production prospect.

Semi-catalytic reduction of secondary amides to imines and aldehydes

Secondary amides can be reduced by silane HSiMe2Ph into imines and aldehydes by a two-stage process involving prior conversion of amides into iminoyl chlorides followed by catalytic reduction mediated by the ruthenium complex [Cp(i-Pr3P)Ru(NCCH3)2]PF6 (1). Alkyl and aryl amides bearing halogen, ketone, and ester groups were converted with moderate to good yields under mild reaction conditions to the corresponding imines and aldehydes. This procedure does not work for substrates bearing the nitro-group and fails for heteroaromatic amides. In the case of cyano substituted amides, the cyano group is reduced to imine.

METHOD FOR THE CATALYTIC REDUCTION OF ACID CHLORIDES AND IMIDOYL CHLORIDES

The present application relates to methods for the catalytic reduction of acid chlorides and/or imidoyl chlorides. The methods comprise reacting the acid chloride or imidoyl chloride with a silane reducing agent in the presence of a catalyst such as [Cp(Pri3P)Ru(NCMe)2]+[PF6]?.

Water-promoted one-pot vinylogous Mannich-type reaction of trimethylsilyloxyfuran

Water, produced in situ during the formation of imines from aldehydes 1 and amines 2, is employed to promote the one-pot Mannich reaction of trimethylsilyloxyfuran 3a without addition of extra solvent or catalyst. This clean and quick reaction allows the obtention of a series of 5-substituted γ-butenolides 4 with good yields and modest diastereomeric ratio. A large panel of substituents is tolerated ranging from aliphatic chains to aromatic or heteroaromatic rings.

Mild and efficient PtO2-catalyzed one-pot reductive mono-N-alkylation of nitroarenes

(Chemical Equation Presented) A mild and efficient one-pot reductive monoalkylation of nitroarenes has been described using aldehydes as alkylating agents, molecular hydrogen as a reducing agent, and PtO2 as a catalyst in methanol. This methodology is found to be applicable for both aliphatic and aromatic aldehydes and for a wide variety of nitroarenes. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Commuications to view the free supplemental file. Copyright Taylor & Francis Group, LLC.

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists

Novel quaternary ammonium derivatives of N,N-disubstituted (3R)-quinuclidinyl carbamates have been identified as potent M3 muscarinic antagonists with long duration of action in an in vivo model of bronchoconstriction. These compounds have also presented a high level of metabolic transformation (human liver microsomes). The synthesis, structure-activity relationships and biological evaluation of these compounds are reported.

Titania-supported iridium subnanoclusters as an efficient heterogeneous catalyst for direct synthesis of quinolines from nitroarenes and aliphatic alcohols

A versatile heterogeneous catalyst consisting of sub-nanosized iridium clusters deposited on titania (Ir/TiO2-NCs) promotes the direct tandem synthesis of quinoline derivatives from readily available nitroarenes and aliphatic alcohols under mild and additive-free conditions (see scheme). The process tolerates the presence of various reactive functional groups and is highly selective.

Synthesis of imines from nitrobenzene and TiO2 particles suspended in alcohols via semiconductor photocatalysis type B

UV irradiation on a non-aqueous suspension of titanium dioxide with nitrobenzene and different alcohols in deaerated conditions produces imines and aniline as main products. The conversion of nitrobenzene and the corresponding selectivity of imines or aniline depend on the type of alcohol used. A low conversion (3-12%) and selectivity close to 100% to imines were obtained with methyl, ethyl, or propyl alcohol. Otherwise, using i-propanol only aniline was detected with a conversion of 13%. Finally, a mixture of aniline and imines was formed employing n-butyl, n-amyl, and i-amyl alcohols with the higher conversion (～50%).