674773-12-7

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 5-AMINO-4-CYANO-3-(2-METHOXY-2-OXOETHYL)THIOPHENE-2-CARBOXYLATE is used as an intermediate in the synthesis of pharmaceutical compounds for [application reason]. Its unique chemical structure allows it to be a key component in the development of new drugs and therapies.
Used in Preparation of Strontium Ranelate (S687700):
METHYL 5-AMINO-4-CYANO-3-(2-METHOXY-2-OXOETHYL)THIOPHENE-2-CARBOXYLATE is used as an intermediate for the preparation of Strontium Ranelate (S687700) for [application reason]. Strontium Ranelate is a medication used to treat osteoporosis, and METHYL 5-AMINO-4-CYANO-3-(2-METHOXY-2-OXOETHYL)THIOPHENE-2-CARBOXYLATE plays a crucial role in its synthesis, contributing to its development and production.

InChI:InChI=1/C10H10N2O4S/c1-15-7(13)3-5-6(4-11)9(12)17-8(5)10(14)16-2/h3,12H2,1-2H3

Upstream product

• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 1208314-91-3 3-(dicyanomethylene)-5-hydroxy-5-methoxy-4-pentenoic acid methyl ester imidazolinium 
• 109-77-3 malononitrile 

Downstream Products

• 674800-87-4 5-[bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic acid methyl ester 
• 674773-13-8 methyl 5-[bis(2-methoxy-2-oxoethyl)amino]-4-cyano-3-(2-methoxy-2-oxoethyl)-2-thiophenecarboxylate 

Relevant academic research and scientific papers

IMPROVED PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE HYDRATES AND NEW POLYMORPHIC FORM OF MONOHYDRATE

The present invention relates to an improved process for preparation of pure strontium ranelate hydrates (Ia-c) by using the intermediates, amino dimethyl ester (II) and tetramethyl ester (III), which are prepared by novel methods. The present invention also relates to a new crystalline polymorphic form of strontium ranelate monohydrate Form F, and process for the preparation thereof. Formula (Ia-c) : Ia- Strontium ranelate octahydrate: n=8 Ib- Strontium ranelate tetrahydrate: n=4 Ic- Strontium ranelate monohydrate: n=1 Formula (II) and Formula (III).

PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE

The present invention relates to an improved process for the synthesis of strontium ranelate or hydrates thereof. More particularly, the present invention relates to an effective process for the preparation of a compound of formula III, which is a useful intermediate in the synthesis of strontium ranelate. wherein R1 and R2 represents substituted or unsubstituted linear or branched C1-C6 alkyl group or C3-C12 cyclic group.

A PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE

The present invention relates to an improved process for the synthesis of strontium ranelate or hydrates thereof. More particularly, the present invention relates to an effective process for the preparation of a compound of formula (III), which is a useful intermediate in the synthesis of strontium ranelate wherein R1 and R2 represents substituted or unsubstituted linear or branched C1-C6 alkyl group or C3-C12 cyclic group.

Process for the industrial synthesis of strontium ranelate and its hydrates

Process for the industrial synthesis of strontium ranelate of formula (I): and its hydrates.

Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates

Process for the industrial synthesis of the compound of formula (I): Application to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.