674773-13-8

Basic information

• Product Name: StrontiuM Ranelate IMpurity B
• Synonyms: StrontiuM Ranelate IMpurity B
• CAS NO: 674773-13-8
• Molecular Formula: Sr
• Molecular Weight: 87.62
• Mol File: 674773-13-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 541.825°C at 760 mmHg
• Flash Point: 281.486°C
• Appearance: /
• Density: 1.384g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.55
• PKA: -4.24±0.50(Predicted)
• CAS DataBase Reference: StrontiuM Ranelate IMpurity B(CAS DataBase Reference)
• NIST Chemistry Reference: StrontiuM Ranelate IMpurity B(674773-13-8)
• EPA Substance Registry System: StrontiuM Ranelate IMpurity B(674773-13-8)

Safety Data

• Hazardous Substances Data: 674773-13-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H18N2O8S/c1-23-11(19)5-9-10(6-17)15(27-14(9)16(22)26-4)18(7-12(20)24-2)8-13(21)25-3/h5,7-8H2,1-4H3

Upstream product

• 674773-12-7 methyl 5-amino-4-cyano-3-(2-methoxy-2-oxoethyl)-2-thiophene-carboxylate 
• 96-32-2 bromoacetic acid methyl ester 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 67-56-1 methanol 
• 674773-14-9 5-amino-3-(carboxymethyl)-4-cyano-2-thiophenecarboxylic acid 

Relevant articles and documents

IMPROVED PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE HYDRATES AND NEW POLYMORPHIC FORM OF MONOHYDRATE

The present invention relates to an improved process for preparation of pure strontium ranelate hydrates (Ia-c) by using the intermediates, amino dimethyl ester (II) and tetramethyl ester (III), which are prepared by novel methods. The present invention also relates to a new crystalline polymorphic form of strontium ranelate monohydrate Form F, and process for the preparation thereof. Formula (Ia-c) : Ia- Strontium ranelate octahydrate: n=8 Ib- Strontium ranelate tetrahydrate: n=4 Ic- Strontium ranelate monohydrate: n=1 Formula (II) and Formula (III).

Process for the industrial synthesis of tetraesters of 5-[BIS(CARBOXYMETHYL)AMINO]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates

Process for the industrial synthesis of compounds of formula (I): wherein R and R′ which are the same or different, each represent linear or branched (C1-C6)alkyl. Application to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.