67488-67-9

Upstream product

• 143-33-9 sodium cyanide 
• 52682-03-8 (S)(-)-N,O-bis(p-toluenesulphonyl)-2-hydroxymethyl pyrrolidine 
• 98-59-9 p-toluenesulfonyl chloride 
• 147-85-3 L-proline 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 

Downstream Products

• 67488-68-0 (-)-(S)-[N-(p-tolylsulfonyl)-2-pyrrolidinyl]acetic acid 
• 227018-72-6 1-(1-(4-methylbenzenesulfonyl)-2-pyrrolidinyl)-2-propanone 
• 847062-76-4 (-)-(S)-[N-(p-tolylsulfonyl)-2-pyrrolidinyl]acetone 
• 847062-77-5 (-)-(2S,2'R)-N-(p-tolylsulfonyl)-2-pyrrolidinyl-2-propanol 
• 847062-72-0 diethyl (-)-(S)-{[N-(p-tolylsulfonyl)-2-pyrrolidinyl]acetyl}malonate 
• 847062-79-7 (2R,2'S)-1-methyl-2-[N-(p-tolylsulfonyl)-2-pyrrolidinyl]ethyl 2,3,4-tri-O-acetyl-β-L-fucopyranoside 
• 847062-80-0 (2S,2'R)-1-methyl-2-[N-(p-tolylsulfonyl)-2-pyrrolidinyl]ethyl 2,3,4-tri-O-acetyl-β-L-fucopyranoside 

Relevant academic research and scientific papers

Total synthesis and identification of two diastereoisomers of 1-methyl-2-[N-(p-tolylsulfonyl)-2-pyrrolidinyl]ethyl β-L-fucopyranoside

The reaction of a racemic mixture of (2R,2′S)- and (2S,2′R)-N-(p-tolylsulfonyl)-2-pyrrolidinyl-2-propanol, prepared from (S)-proline, with 2,3,4-tri-O-acetyl-α-l-fucopyranosyl trichloroacetimidate led to both diastereoisomers of the title compound after O-deacetylation.

Biphenyl derivatives and drug composition

A biphenyl derivative represented by the following general formula (1) and a pharmaceutically acceptable salt thereof: [In the formula (1), A represents a single bond, —CH2—, —CO—, —CS— or —SO2—; B represents a single bond or —CH2—; R1represents a hydrogen atom, —OH, —NR11R12(wherein R11and R12each independently represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms), —OCOCH3, or a halogen atom; R2represents a hydrogen atom or R1and R2form a group ═O together; R3represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; provided that in the formula, the absolute configuration of the position a may be either R or S]. The compound of the present invention has considerably high safety and efficacy and is useful as, in particular, a vasopressin receptor antagonist.