67528-24-9

Basic information

• Product Name: (1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol
• Synonyms: (1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol
• CAS NO: 67528-24-9
• Molecular Weight: 213.074
• Mol File: 67528-24-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol(67528-24-9)
• EPA Substance Registry System: (1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol(67528-24-9)

Safety Data

• Hazardous Substances Data: 67528-24-9(Hazardous Substances Data)

Usage

General Description

(1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol, also known as (1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol, is an organic compound with the molecular formula C9H9BrO. It is a chiral compound, meaning it has a non-superimposable mirror image, and exists as a pair of enantiomers. This chemical is known for its use in asymmetric synthesis and as a building block in the production of pharmaceuticals and other organic compounds. It is also used in the synthesis of natural products and chiral ligands for catalytic reactions. Additionally, (1S,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol has applications in the field of medicinal chemistry and is being explored for its potential biological activity.

Upstream product

• 10368-44-2 trans-2-bromo-1-indanol 
• 108-22-5 Isopropenyl acetate 
• 95-13-6 1-indene 
• 214603-19-7 2,3-dihydro-1-oxo-1H-inden-2-yl-4-methylbenzenesulfonate 
• 85354-33-2 (+)-(1S,2S)-trans-2-bromo-1-(methyloxyacetoxy)indan 
• 5837-70-7 (±)-trans-2-bromo-2,3-dihydro-1H-inden-1-yl acetate 

Downstream Products

• 142678-92-0 (1R,2S)-amino indanol 
• 163061-74-3 (1S,2S)-1-amino-2,3-dihydro-1H-inden-2-ol 
• 768-22-9 (1S,2R)-epoxyindane 

Relevant articles and documents

A convenient synthesis of (1S,2R)-1,2-indene oxide and trans-(1S,2S)-2-bromo-1-indanol via oxazaborolidine-catalyzed borane reduction

A facile synthesis of (1S,2R)-indene oxide with >99% e.e. and (1S,2S)-trans-2-bromo-1-indanol with 87% e.e. has been established by employing CBS-oxazaborolidine-catalyzed asymmetric borane reduction of 2-p-toluenesulfonyloxy-1-indanone using N-ethyl-N-isopropylaniline-borane complex as the borane carrier.

Synthesis of enantiomerically pure (1S, 2R)-epoxy indane and cis-(1R, 2S)-2-amino-1-indanol

Enantiomerically pure (1S, 2R)-epoxy indane and cis-(1R, 2S)-2-amino-1-indanol were synthesized via highly enantioselective lipase catalyzed transesterification of racemic trans-2-bromo-1-indanol.

Halohydrin and its derivatives low priced high-efficient synthetic method (by machine translation)

The invention discloses a halohydrin low priced high-efficient synthetic method, the organic solvent of formula I shown in the olefin compound with a halide, sulfoxide and additive mixing, by the olefin of hydroxy halogenate reaction, can be a high selectivity of the halohydrin the system results in the type II shown, wherein R1 , R2 , R3 , R4 , R5 And R6 Are selected from hydrogen, halogen, alkyl, hydroxyalkyl, alkoxy, ester, acyl, amido, dialkyl amino, aryl, substituted aromatic, heterocyclic aromatic group or substituted heterocyclic aromatic, R1 , R2 , R3 , R4 , R5 And R6 The presence of the respective independent may be identical or different; or R1 And R2 , R1 And R3 , R2 And R4 , R3 And R4 , R5 And R6 Combining to form a cycloalkyl or substituted cycloalkyl, benzo ring alkyl or substituted cycloalkyl, heterocycle or substituted heterocycle; M selected from hydrogen, lithium, sodium, potassium, cesium, beryllium, magnesium, calcium, strontium, barium, zinc, copper, iron, ammonium or tetraalkyl ammonium; X chlorine, bromine or iodine. (by machine translation)