Enzymatic resolution of indene bromohydrin acetate using immobilized lipase

Article abstract of DOI:10.1016/S0957-4166(97)00351-0

Enzymatic resolution of indene bromohydrin acetate by hydrolysis or alcoholysis in the presence of immobilized lipase from Candida antarctica (Novozym 435) has been investigated. Enantiomerically enriched (1S,2S)-(+)-2-bromoindan-1-ol and (1R,2R)-(-)-1-acetoxy-2-bromoindan were obtained when indene bromohydrin acetate was treated with Novozym 435 and cyclohexanol in dibutyl ether for 30 hours at 40°C.