6761-19-9

Upstream product

• 118-92-3 anthranilic acid 
• 98-88-4 benzoyl chloride 
• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 1904-60-5 3-amino-2-phenylquinazolin-4(3H)-one 
• 609-65-4 o-chlorobenzoyl chloride 

Relevant academic research and scientific papers

Quinazolinones with amide linkage: Synthesis and antimicrobial activity

Treatment of anthranilic acid in pyridine with benzoyl chloride gives 2-phenyl-3,1-benzoxazine-4-one (I). 3-Amino-2-phenylquinazol-4-one (II) was synthesized by reaction of 2-phenyl-3,1-benzoxazine-4-one I with hydrazine hydrate (80%) in ethanol. Aseries of amides were synthesized by treatment of various substituted acid chlorides with 3amino-2-phenylquinazol-4-one using pyridine as solvent. All the synthesized compounds were characterized by elemental analysis and spectral data. They were screened for antibacterial activity against E. coli and S. aureus and for antifungal activity against A. niger by cup plate method at 1 μg/ml cone in DMF. All the synthesized compounds showed good to moderate antimicrobial activity.

Quinazolinone derivatives: Synthesis and binding evaluation on cholecystokinin receptors

A series of 2-methyl-3-amino-4(H)-quinazolinone and of 2-phenyl-3-amino-4(H)-quinazolinone derivatives were synthesized and examined for their CCK receptor affinities. These compounds displayed micromolar affinities for CCK-B rather than CCK-A receptor and the obtained results confirm that the 4(3H)-quinazolinone nucleous represent a useful template for the development of selective CCK-B receptor ligands.