6761-23-5

Upstream product

• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 618-94-0 3-nitrobenzoic acid hydrazide 
• 98-88-4 benzoyl chloride 
• 1904-60-5 3-amino-2-phenylquinazolin-4(3H)-one 
• 121-90-4 m-nitrobenzoic acid chloride 
• 118-92-3 anthranilic acid 
• 28864-29-1 N-anthraniloyl-N'-(3-nitro-benzoyl)-hydrazine 
• 905235-31-6 N-(N-benzoyl-anthraniloyl)-N'-(3-nitro-benzoyl)-hydrazine 

Relevant academic research and scientific papers

Quinazolinones with amide linkage: Synthesis and antimicrobial activity

Treatment of anthranilic acid in pyridine with benzoyl chloride gives 2-phenyl-3,1-benzoxazine-4-one (I). 3-Amino-2-phenylquinazol-4-one (II) was synthesized by reaction of 2-phenyl-3,1-benzoxazine-4-one I with hydrazine hydrate (80%) in ethanol. Aseries of amides were synthesized by treatment of various substituted acid chlorides with 3amino-2-phenylquinazol-4-one using pyridine as solvent. All the synthesized compounds were characterized by elemental analysis and spectral data. They were screened for antibacterial activity against E. coli and S. aureus and for antifungal activity against A. niger by cup plate method at 1 μg/ml cone in DMF. All the synthesized compounds showed good to moderate antimicrobial activity.

Synthesis of substituted quinazolone derivatives as potential anti-HIV agents (part III)

Several 1-[2-phenyl-4(4H)-oxo-3-quinazolinyl]-2-methyl-4-arylidine -5-oxo-imidazolines (Va-1), 2-phenyl-3-(aroyl amino)-4(4H)-oxo quinazolines (Vla-I) and N1-2-methyl-4(4H)-oxo-3-quinazolinyl-N2-aryl-thioureas (Vlla-k), have been synthesised and tested for anti-HIV activity. The structures of these compounds have been established on the basis of elemental analysis and spectral data.