676129-92-3

Usage

Uses

Used in Pharmaceutical Industry:
S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)aMino)-3Methylbutanoic acid is used as an antihypertensive agent for the treatment of high blood pressure. It functions by blocking the action of angiotensin II, a potent vasoconstrictor, thereby reducing blood pressure and alleviating the workload on the heart.
Used in Cardiology:
In the field of cardiology, S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)aMino)-3Methylbutanoic acid is utilized to manage congestive heart failure. Its ability to lower blood pressure and improve cardiac function makes it a valuable asset in the treatment of heart disease, enhancing patient outcomes and survival rates post-heart attack.
Despite its therapeutic benefits, S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)aMino)-3Methylbutanoic acid may also induce side effects such as dizziness, hypotension, and hyperkalemia, which underscores the importance of careful patient monitoring and dosage adjustment as needed.

Upstream product

• 151052-40-3 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde 
• 72-18-4 L-valine 
• 676129-91-2 3-methyl-2{[1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]-meth-(E/Z)-ylidene]-amino}-butyric acid 
• 482577-59-3 N-((2'-cyano[1,1'-biphenyl]-4-yl)methyl)-L-valine methyl ester hydrochloride 
• 137862-53-4 N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine 
• 133292-05-4 4-(diethoxymethyl)phenylmagnesium bromide 
• 34421-94-8 4-bromobenzaldehyde diethyl acetal 
• 73096-42-1 5-(2-bromophenyl)-1H-tetrazole 
• 676130-06-6 5-(4'-diethoxymethyl-biphenyl-2-yl)-2-(tetrahydro-pyran-2-yl)-2H-tetrazole 
• 676130-02-2 5-(2-bromophenyl)-2-(tetrahydropyran-2-yl)-2H-tetrazole 

Downstream Products

• 137862-53-4 N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine 
• 2254485-68-0 C₁₉H₂₀N₆O₃ 

Relevant academic research and scientific papers

Preparation method of valsartan nitrite remainder

The invention discloses a preparation method of valsartan nitrite remainder, which belongs to the technical field of a preparation method of a chemical drug midbody. Valsartan is used as a raw material to have hydrolysis and nitrosation reaction to prepar

An efficient and telescopic process for valsartan, an angiotensin II Receptor Blocker

An efficient, telescopic, and scalable process for an antihypertensive drug substance, valsartan with an overall yield of 58%, and ～99.9% purity is described. A simple, and safe process is developed for the recovery of tributyltin chloride from the tributyltin hydroxide, byproduct formed in the tetrazole ring construction, and reused in the synthesis of valsartan.

PROCESS FOR THE PREPARATION OF TETRAZOLE DERIVATIVES FROM ORGANO BORON AND ORGANO ALUMINIUM AZIDES

The present invention relates to a method for preparing substituted tetrazoles, compounds obtained according to this method, new reactants and new tetrazole derivatives.

PROCESS FOR THE MANUFACTURE OF VALSARTAN

The present invention relates to a process for the manufacture of Valsartan, an angiotensin receptor blocker (ARB; also called angiotension II receptor antagonist or AT1 receptor antagonist) and salts thereof, to novel intermediates and process steps.