151052-40-3

Usage

Uses

Used in Pharmaceutical Industry:
2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde is used as an impurity in the production of Losartan Potassium (L470500), an angiotensin II antagonist. It plays a role in the development and formulation of this medication, which is crucial for managing high blood pressure and heart failure in patients.
Additionally, as an impurity in Losartan Potassium, 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde contributes to the drug's effectiveness in significantly reducing the risk of new onset atrial fibrillation and associated stroke in high-risk patients. This makes it an important component in the pharmaceutical industry for the development and production of life-saving medications.

Upstream product

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• 87199-17-5 4-formylphenylboronic acid, 
• 135689-93-9 4-(2-Cyanophenyl)benzaldehyde 
• 160514-13-6 5-(4'-hydroxymethyl-biphenyl-2-yl)-1H-tetrazole 
• 676130-00-0 5-(2-chlorophenyl)-2-(tetrahydropyran-2-yl)-2H-tetrazole 
• 676130-01-1 5-(2-chlorophenyl)-1-(tetrahydropyran-2-yl)-1H-tetrazole 
• 24856-58-4 1,1-dimethoxy-1-(4-bromophenyl)methane 
• 133292-05-4 4-(diethoxymethyl)phenylmagnesium bromide 
• 34421-94-8 4-bromobenzaldehyde diethyl acetal 
• 676130-02-2 5-(2-bromophenyl)-2-(tetrahydropyran-2-yl)-2H-tetrazole 
• 676130-06-6 5-(4'-diethoxymethyl-biphenyl-2-yl)-2-(tetrahydro-pyran-2-yl)-2H-tetrazole 
• 154709-19-0 4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile 

Relevant academic research and scientific papers

Efficient, protection-free Suzuki-Miyaura synthesis of ortho- biphenyltetrazoles

We describe an efficient protocol for the Suzuki-Miyaura synthesis of ortho-biphenyltetrazoles from non-protected 2-bromophenyltetrazole and arylboronic acids. The optimised conditions were achieved using [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) as catalyst and Na2CO3 as base. A panel of structurally diverse arylboronic acids was used to demonstrate the scope of the coupling procedure.

PROCESS FOR PRODUCING 2' -(1H-TETRAZOL-5-YL)-BIPHENYL-4-CARBALDEHYDE

The present invention provides a process for producing 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde which comprises reacting 2'-cyanobiphenyl-4-carbaldehyde with a salt of azide; a process for producing a highly pure crystal of 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde which comprises reacting 2'-cyanobiphenyl-4-carbaldehyde with a salt of azide, obtaining a crystal of 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde, dissolving said crystal obtained and recrystallizing a highly pure crystal in tetrahydrofuran; and the like. According to the present process, 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde which is useful as a synthetic intermediate of medicines can be produced in a short process at high yield and high purity.

COUPLING REACTIONS USEFUL IN THE PREPARATION OF (1H-TETRAZOL-5-YL)-BIPHENYL DERIVATIVES

The present invention relates to a process for the manufacture of intermediates that may be used for the manufacture of ARBs (also called angiotension II receptor antagonists or AT1 receptor antagonists) comprising as a common structural feature a (lH-tet

2'-(1H-TETRAZOL-5-YL)BIPHENYL-4-CARBALDEHYDE CRYSTAL AND ITS MANUFACTURING METHOD

PROBLEM TO BE SOLVED: To provide a method for industrially manufacturing 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde crystal of high purity with a high yield in a short step using an inexpensive reagent. SOLUTION: The manufacturing method of 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde crystal of high purity comprises a step for reacting 2'-cyanobiphenyl-4-carbaldehyde with an azide salt and a step for crystallizing the crude 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde crystal obtained by the above step from tetrahydrofuran.

PROCESS FOR THE PREPARATION OF TETRAZOLE DERIVATIVES FROM ORGANO BORON AND ORGANO ALUMINIUM AZIDES

The present invention relates to a method for preparing substituted tetrazoles, compounds obtained according to this method, new reactants and new tetrazole derivatives.

PROCESS FOR THE MANUFACTURE OF VALSARTAN

The present invention relates to a process for the manufacture of Valsartan, an angiotensin receptor blocker (ARB; also called angiotension II receptor antagonist or AT1 receptor antagonist) and salts thereof, to novel intermediates and process steps.

2-(tetrazol-5-yl)-1,1'-biphenyl derivatives, their preparation and their use as synthetic intermediates

Compounds corresponding to the formula (I) STR1 in which X represents dibromomethyl, formyl, (C1-4)alkyl, or a group CH(OR5)2 or CH(OH)OR5, wherein the or each R5 is hydrogen (C1-3)alkyl or the two R5 's in the case of CH(OR5)2 are linked to provide a 1,3-dioxolane or 1,3-dioxane ring, and Y represents hydrogen, 1,1-dimethylethyl, triphenylmethyl, trimethylstannyl, tributylstannyl, (1,1-dimethylethyl)dimethylsilyl, (1,1-dimethylethyl)diphenylsilyl, 2-cyanoethyl, or a group CH2 OR6 wherein R6 is methyl, phenylmethyl, 1,1-dimethylethyl, 2,2,2-trichloroethyl, benzyloxycarbonyl or 2,2,2-trichloroethyloxycarbonyl, Y being in position 1 or 2 on the tetrazole ring. The compounds of formula (I) are useful as intermediates in the synthesis of compounds possessing therapeutic activity.