67622-86-0

Usage

Uses

Used in Pharmaceutical Industry:
2-METHYL-1-(METHYLAMINO)PROPAN-2-OL is used as a reagent for the synthesis of thiophene-anthranilamides, which are potent and orally active factor Xa inhibitors. These inhibitors play a crucial role in the development of anticoagulant medications, helping to prevent blood clot formation and related complications.

InChI:InChI=1/C5H13NO/c1-5(2,7)4-6-3/h6-7H,4H2,1-3H3

Upstream product

• 558-30-5 2-methyl-1,2-epoxypropane 
• 74-89-5 methylamine 
• 558-42-9 3-chloro-2-methylpropan-2-ol 
• 50-00-0 formaldehyd 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 

Downstream Products

• 40278-47-5 methyl-(2-methyl-2-phenyl-propyl)-amine 

Relevant academic research and scientific papers

Efficient Aluminum Catalysts for the Chemical Conversion of CO2 into Cyclic Carbonates at Room Temperature and Atmospheric CO2 Pressure

A series of dimeric aluminum compounds [Al(OCMe2CH2N(R)CH2X)]2 [X=pyridin-2-yl, R=H (PyrH); X= pyridin-2-yl, R=Me (PyrMe); X=furan-2-yl, R=H (FurH); X= furan-2-yl, R=Me (FurMe); X=thiophen-2-yl, R=H (ThioH); X= thiophen-2-yl, R=Me (ThioMe)] containing heterocyclic pendant group attached to the nitrogen catalyze the coupling of CO2 with epoxides under ambient conditions. In a comparison of their catalytic activities with those of aluminum complexes without pendant groups at N [X=H, R=H (HH); X=H, R=Me (HMe)] or with non-heterocyclic pendant groups [X=CH2CH2OMe, R=H (OMeH); X=CH2CH2NMe2, R=H (NMe2H); X=CH2CH2NMe2, R=Me (NMe2Me)], complexes containing heterocycles, in conjunction with (nBu)4NBr as a cocatalyst, show higher catalytic activities for the synthesis of cyclic carbonates under the same ambient conditions. The best catalyst system for this reaction is PyrH/(nBu)4NBr system, which gives a turnover number of 99 and a turnover frequency of 4.1 h?1, making it 14- and 20-times more effective than HH/(nBu)4NBr and HMe/(nBu)4NBr, respectively. Although there are no direct interactions between the aluminum and the heteroatoms in the heterocyclic pendants, electronic effects combined with the increased local concentration of CO2 around the active centers influences the catalytic activity in the coupling of CO2 with epoxides. In addition, PyrH/(nBu)4NBr shows broad epoxide substrate scope and seven terminal epoxides and two internal epoxides undergo the designed reaction.

Cis versus Trans: The Coordination Environment about the Tin(IV) Atom in Spirocyclic Amino Alcohol Derivatives

The syntheses of amino alcohols MeN(CH2CH2CMe2OH)2 (1), MeN(CMe2CH2OH)(CH2CMe2OH) (2), MeN(CH2CH2CH2OH)(CH2CMe2OH) (3), MeN(CH2CH2CMe2OH)(CH2CMe2OH) (4), MeN(CH2CH2CMe2OH)(CH2CH2OH) (5), and MeN(CH2CH2OH) (CH2CH2CH2OH) (6) as well as spirocyclic tin(IV) alkoxides spiro-[nBuN(CH2CMe2O)2]2Sn (7), spiro-[MeN(CH2CH2CMe2O)2]2Sn (8), spiro-[para-FC6H4N (CH2CMe2O)2]2Sn (9), spiro-[MeN(CMe2CH2O)(CH2CMe2O)]2Sn (10), spiro-[MeN(CH2CH2CH2O)(CH2CMe2O)]2Sn (11), spiro-[MeN(CH2CH2CMe2O)(CH2CMe2O)]2Sn (12), spiro-[MeN(CH2CH2CMe2O)(CH2CH2O)]2Sn (13) and spiro-[MeN(CH2CH2O)(CH2CH2CH2O)]2Sn (14) are reported. The compounds were characterized by 1H, 13C (1–14) and 119Sn (7–14) NMR and IR spectroscopy, EIMS and single-crystal XRD (2, 7–10 and 13, 14). Graph-set analyses were performed for compounds [(MeNH(CMe2CH2OH)(CH2CMe2OH)][HC(O)O] (2 a) and 2. The coordination environment about the tin(IV) centre of the spirocyclic compounds and their possible stereoisomers were analysed by DFT calculations (spiro-[MeN(CH2CMe2O)2]2Sn, 8–10 and 13).

IMIDAZOLE DERIVATIVE

A CB2 receptor modulator comprising an imidazole derivative represented by the general formula (I): [wherein, R1 represents optionally substituted lower alkyl or the like; R2 represents optionally substituted cycloalkyl or the like; R3 represents optionally substituted aryl or the like; and n represents an integer of 0 to 3] or a pharmaceutically acceptable salt thereof as an active ingredient, and the like are provided.