67622-86-0

Basic information

• Product Name: 2-METHYL-1-(METHYLAMINO)PROPAN-2-OL
• Synonyms: 2-METHYL-1-(METHYLAMINO)PROPAN-2-OL;MFCD11043099
• CAS NO: 67622-86-0
• Molecular Formula: C₅H₁₃NO
• Molecular Weight: 103.16282
• Mol File: 67622-86-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 162.182°C at 760 mmHg
• Flash Point: 62.437°C
• Appearance: /
• Density: 0.878g/cm³
• Vapor Pressure: 0.755mmHg at 25°C
• Refractive Index: 1.43
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 14.97±0.29(Predicted)
• CAS DataBase Reference: 2-METHYL-1-(METHYLAMINO)PROPAN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-1-(METHYLAMINO)PROPAN-2-OL(67622-86-0)
• EPA Substance Registry System: 2-METHYL-1-(METHYLAMINO)PROPAN-2-OL(67622-86-0)

Safety Data

• Hazardous Substances Data: 67622-86-0(Hazardous Substances Data)

Usage

Uses

2-?Methyl-?1-?(methylamino)?-?2-?propanol is a general reagent used in the synthesis of thiophene-anthranilamides which act as potent and orally active factor Xa inihibitors.

InChI:InChI=1/C5H13NO/c1-5(2,7)4-6-3/h6-7H,4H2,1-3H3

Upstream product

• 50-00-0 formaldehyd 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 558-30-5 2-methyl-1,2-epoxypropane 
• 74-89-5 methylamine 
• 558-42-9 3-chloro-2-methylpropan-2-ol 

Downstream Products

• 40278-47-5 methyl-(2-methyl-2-phenyl-propyl)-amine 

Relevant articles and documents

Efficient Aluminum Catalysts for the Chemical Conversion of CO2 into Cyclic Carbonates at Room Temperature and Atmospheric CO2 Pressure

A series of dimeric aluminum compounds [Al(OCMe2CH2N(R)CH2X)]2 [X=pyridin-2-yl, R=H (PyrH); X= pyridin-2-yl, R=Me (PyrMe); X=furan-2-yl, R=H (FurH); X= furan-2-yl, R=Me (FurMe); X=thiophen-2-yl, R=H (ThioH); X= thiophen-2-yl, R=Me (ThioMe)] containing heterocyclic pendant group attached to the nitrogen catalyze the coupling of CO2 with epoxides under ambient conditions. In a comparison of their catalytic activities with those of aluminum complexes without pendant groups at N [X=H, R=H (HH); X=H, R=Me (HMe)] or with non-heterocyclic pendant groups [X=CH2CH2OMe, R=H (OMeH); X=CH2CH2NMe2, R=H (NMe2H); X=CH2CH2NMe2, R=Me (NMe2Me)], complexes containing heterocycles, in conjunction with (nBu)4NBr as a cocatalyst, show higher catalytic activities for the synthesis of cyclic carbonates under the same ambient conditions. The best catalyst system for this reaction is PyrH/(nBu)4NBr system, which gives a turnover number of 99 and a turnover frequency of 4.1 h?1, making it 14- and 20-times more effective than HH/(nBu)4NBr and HMe/(nBu)4NBr, respectively. Although there are no direct interactions between the aluminum and the heteroatoms in the heterocyclic pendants, electronic effects combined with the increased local concentration of CO2 around the active centers influences the catalytic activity in the coupling of CO2 with epoxides. In addition, PyrH/(nBu)4NBr shows broad epoxide substrate scope and seven terminal epoxides and two internal epoxides undergo the designed reaction.

IMIDAZOLE DERIVATIVE

A CB2 receptor modulator comprising an imidazole derivative represented by the general formula (I): [wherein, R1 represents optionally substituted lower alkyl or the like; R2 represents optionally substituted cycloalkyl or the like; R3 represents optionally substituted aryl or the like; and n represents an integer of 0 to 3] or a pharmaceutically acceptable salt thereof as an active ingredient, and the like are provided.