2-Methyl-1-(methylamino)propan-2-ol

Base Information

• Chemical Name: 2-Methyl-1-(methylamino)propan-2-ol
• CAS No.: 67622-86-0
• Molecular Formula: C5H13NO
• Molecular Weight: 103.164
• Hs Code.: 2922199090
• DSSTox Substance ID: DTXSID70540625
• Wikidata: Q82416684
• Mol file: 67622-86-0.mol

Synonyms:2-Methyl-1-(methylamino)propan-2-ol;67622-86-0;2-METHYL-1-METHYLAMINO-PROPAN-2-OL;2-methyl-1-(methylamino)-2-propanol;MFCD11043099;2-methyl-1-(methylamino) propan-2-ol;2-Propanol, 2-methyl-1-(methylamino)-;SCHEMBL469067;DTXSID70540625;KYCZVVFGMGLNPL-UHFFFAOYSA-N;AKOS008140548;SB38256;AM807013;BS-12732;SY123563;CS-0038213;EN300-77367;W12311;Z600453550

Chemical Property of 2-Methyl-1-(methylamino)propan-2-ol

Chemical Property:

• Vapor Pressure: 0.755mmHg at 25°C
• Boiling Point: 142-143 °C
• PKA: 14.97±0.29(Predicted)
• PSA: 32.26000
• Density: 0.8875 g/cm3(Temp: 23 °C)
• LogP: 0.36760
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 103.099714038
• Heavy Atom Count: 7
• Complexity: 52

Purity/Quality:

97% ^*data from raw suppliers

2-?Methyl-?1-?(methylamino)?-?2-?propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(CNC)O
• Uses: 2-?Methyl-?1-?(methylamino)?-?2-?propanol is a general reagent used in the synthesis of thiophene-anthranilamides which act as potent and orally active factor Xa inihibitors.

Technology Process of 2-Methyl-1-(methylamino)propan-2-ol

There total 3 articles about 2-Methyl-1-(methylamino)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-methyl-1,2-epoxypropane (558-30-5) + methylamine (74-89-5) → 2-methyl-1-(methylamino)propane-2-ol (67622-86-0)

Guidance literature:

In ethanol; for 2h; Sonication; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201803952

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-hydroxy-2-methylpropanenitrile (75-86-5) → 2-methyl-1-(methylamino)propane-2-ol (67622-86-0) + 1-dimethylamino-2-methyl-propan-2-ol (14123-48-9)

Guidance literature:

With 2-methyl-propan-1-ol; nickel; at 90 - 100 ℃; under 514855 Torr; Hydrogenation;

Reference yield:

3-chloro-2-methylpropan-2-ol (558-42-9) + methylamine (74-89-5) → 2-methyl-1-(methylamino)propane-2-ol (67622-86-0)

Guidance literature:

With water;

DOI:10.1021/ja01267a100

upstream raw materials:

formaldehyd

2-hydroxy-2-methylpropanenitrile

3-chloro-2-methylpropan-2-ol

methylamine

Downstream raw materials:

methyl-(2-methyl-2-phenyl-propyl)-amine