6763-54-8Relevant academic research and scientific papers
Synthesis and evaluation of 3-modified 1D-myo-inositols as inhibitors and substrates of phosphatidylinositol synthase and inhibitors of myo-inositol uptake by cells
Johnson,Dahl,Shih,Schedler,Anderson,Benjamin,Baker
, p. 3628 - 3635 (1993)
A number of 3-substituted 1D-myo-inositols were synthesized and evaluated as substrates for phosphatidylinositol synthase and uptake by intact cells. 1D-3-Amino-, -3-chloro-, and -3-(acetylthio)-3-deoxy-myo-inositols were all synthesized by nucleophilic d
Cyclitol Reactions, V. - Synthesis of Enantiomerically Pure Valienamine from Quebrachitol
Paulsen, Hans,Heiker, Fred R.
, p. 2180 - 2203 (2007/10/02)
An enantioselective synthesis of Valienamine (86) from quebrachitol (L-2O-methyl-chiro-inositol) (1) is described.Valienamine (86) is an unsaturated branched-chain aminocyclitol found in the central structural unit of the antidiabetic drug acarbose.Techniques for the introduction of side chains, azido groups, and double bonds into inositol systems are investigated.The methods developed in this connection are applied in the synthesis of valienamine.
