Synthesis and evaluation of 3-modified 1D-myo-inositols as inhibitors and substrates of phosphatidylinositol synthase and inhibitors of myo-inositol uptake by cells

DOI: 10.1021/jm00075a018

Source and publish data:

Journal of Medicinal Chemistry p. 3628 - 3635 (1993)

Update date:2022-08-04

Topics:

Authors:

Johnson Johnson

Dahl Dahl

Shih Shih

Schedler

Anderson

Benjamin

Baker Baker

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Article abstract of DOI:10.1021/jm00075a018

A number of 3-substituted 1D-myo-inositols were synthesized and evaluated as substrates for phosphatidylinositol synthase and uptake by intact cells. 1D-3-Amino-, -3-chloro-, and -3-(acetylthio)-3-deoxy-myo-inositols were all synthesized by nucleophilic d

Full text of DOI:10.1021/jm00075a018

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