676474-17-2

Upstream product

• 676474-16-1 2,2-dimethyl-propionic acid 6-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienyl ester 
• 676474-14-9 2,2-dimethyl-propionic acid 5-(4-methoxy-benzyloxy)-8-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-oxo-octa-2,7-dienyl ester 
• 676473-77-1 2,2-dimethyl-propionic acid 6-hydroxy-5-(4-methoxy-benzyloxy)-8-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienyl ester 
• 676473-75-9 2,2-dimethyl-propionic acid 7-(dimethoxy-phosphoryl)-5-(4-methoxy-benzyloxy)-6-oxo-hept-2-enyl ester 
• 676473-65-7 7-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2,6-dimethyl-heptane-2,3-diol 
• 676473-73-7 2,2-dimethyl-propionic acid 6,7-dihydroxy-5-(4-methoxy-benzyloxy)-hept-2-enyl ester 
• 849361-63-3 [(E)-(S)-7-Hydroxy-3-(4-methoxy-benzyloxy)-2-oxo-hept-5-enyl]-phosphonic acid dimethyl ester 
• 849361-79-1 2-(3-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl)-propenal 
• 849361-62-2 6-(2,2-dimethyl-propionyloxy)-2-(4-methoxy-benzyloxy)-hex-4-enoic acid 
• 676474-12-7 5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-5-(4-methoxy-benzyloxy)-pent-2-enoic acid methyl ester 
• 849361-78-0 5-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-4-methyl-pentanal 
• 676474-11-6 Acetic acid (S)-4-methyl-2-methylene-5-((2R,6R)-6-prop-2-ynyl-3,6-dihydro-2H-pyran-2-yl)-pentyl ester 
• 849361-77-9 (S)-7-[(2R,6R)-6-(2-Hydroxy-ethyl)-3,6-dihydro-2H-pyran-2-yl]-2,6-dimethyl-heptane-2,3-diol 
• 849361-61-1 2,2-dimethyl-propionic acid 5-(4-methoxy-benzyloxy)-6-oxo-hex-2-enyl ester 

Downstream Products

• 115268-43-4 laulimalide 
• 676474-18-3 6,11-bis-(tert-butyl-dimethyl-silanyloxy)-10-(4-methoxy-benzyloxy)-2-methyl-13-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-4-methylene-1-(6-prop-2-ynyl-3,6-dihydro-2H-pyran-2-yl)-trideca-7,12-diene 

Relevant academic research and scientific papers

LAULIMALIDE ANALOGS AND USES THEREOF

The present invention provides compounds having formula 1: (I) and pharmaceutically acceptable derivatives thereof, wherein R1-R10, q, t, X0, X1, A, B, D, E, G, J, K, L, M and Z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders associated with cellular hyperproliferation.

Synthesis and biological evaluation of (-)-laulimalide analogues

Analogues of the marine natural product (-)-laulimalide were prepared by total synthesis and evaluated in vitro for anticancer activity.