676479-06-4

Basic information

• Product Name: Acetamide, N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-3-pyrrolidinyl]-
• CAS NO: 676479-06-4
• Molecular Formula: C19H19FN2O3
• Molecular Weight: 342.37
• Mol File: 676479-06-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-3-pyrrolidinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-3-pyrrolidinyl]-(676479-06-4)
• EPA Substance Registry System: Acetamide, N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-3-pyrrolidinyl]-(676479-06-4)

Safety Data

• Hazardous Substances Data: 676479-06-4(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 910298-84-9 (S)-1-[4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid amide 
• 676479-40-6 (S)-4-amino-1-[4-(3-fluoro-benzyloxy)-phenyl]-pyrrolidin-2-one hydrochloride 
• 75-36-5 acetyl chloride 
• 456-42-8 m-fluorobenzyl chloride 
• 123-30-8 4-amino-phenol 
• 754228-95-0 (S)-3-acetylamino-y-butyrolactone 
• 4910-47-8 N-Acetyl-asparaginsaeure-α-methylester 
• 57289-64-2 N-α-acetyl-L-aspartic acid α,β-dimethylester 

Downstream Products

• 676479-53-1 (S)-N-[1-(4-hydroxy-phenyl)-5-oxo-pyrrolidin-3-yl]-acetamide 

Relevant articles and documents

CRYSTALLINE FORMS OF A PYRROLIDONE DERIVATIVE USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE AND PREPARATION THEREOF

The present invention provides processes to manufacture crystalline N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-pyrrolidin-3-yl]acetamide. Also disclosed are polymorphic forms of said compound as well as compounds useful as intermediates in the methods of the invention.

Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives

The invention relates to a method for preparing enantiomerically pure 4-pyrrolidinophenylbenzyl ether derivatives of formula I: wherein R1, R21, R22, R23, R24 and n are as defined in the description and claims and to intermediates useful in the method of the invention as well as salts thereof.

PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS

Racemic or enantiomerically pure 4-pyrrolidino derivatives of the formula (I), processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of a disease which is mediated by a mono