676529-99-0

Basic information

• Product Name: 5(4H)-Oxazolone, 4-[(2,4-difluorophenyl)methylene]-2-phenyl-, (4E)-
• CAS NO: 676529-99-0
• Molecular Formula: C16H9F2NO2
• Molecular Weight: 285.25
• Mol File: 676529-99-0.mol

Chemical Properties

• CAS DataBase Reference: 5(4H)-Oxazolone, 4-[(2,4-difluorophenyl)methylene]-2-phenyl-, (4E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(4H)-Oxazolone, 4-[(2,4-difluorophenyl)methylene]-2-phenyl-, (4E)-(676529-99-0)
• EPA Substance Registry System: 5(4H)-Oxazolone, 4-[(2,4-difluorophenyl)methylene]-2-phenyl-, (4E)-(676529-99-0)

Safety Data

• Hazardous Substances Data: 676529-99-0(Hazardous Substances Data)

Upstream product

• 495-69-2 Hippuric Acid 
• 1550-35-2 2,4-difluorobenzaldehyde 

Downstream Products

• 676530-01-1 2,4-difluorophenylpyruvic acid 
• 676530-00-0 Z-4-(2,4-difluorobenzylidene)-2-phenyl-5-oxazolone 

Relevant articles and documents

Phenylpyruvic acid derivatives as enzyme inhibitors: Therapeutic potential on macrophage migration inhibitory factor

Phenylpyruvic acid derivatives are obtained by hydrolysing aromatic Z/E azlactones. Keto tautomers interact with enzyme systems such as phenylalanine dehydrogenase or carboxypeptidase A whereas enol tautomers are potential inhibitors on the phenylpyruvate tautomerase activity catalysed by Macrophage Migration Inhibitory Factor (MIF). MIF being a key molecule in immune and inflammatory processes several structures with reasonable interaction with MIF and protocol for specific synthesis are presented. Birkhaeuser Boston 2004.

Design and synthesis of 2,4-difluorophenylpyruvic acid and of its azlactone precursor for macrophage migration inhibitory factor (MIF) tautomerase activity

The macrophage migration inhibitory factor (MIF) is an important cytokine implicated in several diseases and currently a target for drug development. This study aimed to synthesize phenylpyruvic acid like structures that fit the molecular requirements of