676529-99-0

Basic information

• Product Name: 5(4H)-Oxazolone, 4-[(2,4-difluorophenyl)methylene]-2-phenyl-, (4E)-
• CAS NO: 676529-99-0
• Molecular Formula: C16H9F2NO2
• Molecular Weight: 285.25
• Mol File: 676529-99-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5(4H)-Oxazolone, 4-[(2,4-difluorophenyl)methylene]-2-phenyl-, (4E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(4H)-Oxazolone, 4-[(2,4-difluorophenyl)methylene]-2-phenyl-, (4E)-(676529-99-0)
• EPA Substance Registry System: 5(4H)-Oxazolone, 4-[(2,4-difluorophenyl)methylene]-2-phenyl-, (4E)-(676529-99-0)

Safety Data

• Hazardous Substances Data: 676529-99-0(Hazardous Substances Data)

Upstream product

• 495-69-2 Hippuric Acid 
• 1550-35-2 2,4-difluorobenzaldehyde 

Downstream Products

• 676530-00-0 Z-4-(2,4-difluorobenzylidene)-2-phenyl-5-oxazolone 
• 676530-01-1 2,4-difluorophenylpyruvic acid 

Relevant articles and documents

Phenylpyruvic acid derivatives as enzyme inhibitors: Therapeutic potential on macrophage migration inhibitory factor

Phenylpyruvic acid derivatives are obtained by hydrolysing aromatic Z/E azlactones. Keto tautomers interact with enzyme systems such as phenylalanine dehydrogenase or carboxypeptidase A whereas enol tautomers are potential inhibitors on the phenylpyruvate tautomerase activity catalysed by Macrophage Migration Inhibitory Factor (MIF). MIF being a key molecule in immune and inflammatory processes several structures with reasonable interaction with MIF and protocol for specific synthesis are presented. Birkhaeuser Boston 2004.