676530-00-0Relevant academic research and scientific papers
Phenylpyruvic acid derivatives as enzyme inhibitors: Therapeutic potential on macrophage migration inhibitory factor
Carpy, Alain J. M.,Haasbroek, Petrus P.,Oliver, Douglas W.
, p. 565 - 577 (2007/10/03)
Phenylpyruvic acid derivatives are obtained by hydrolysing aromatic Z/E azlactones. Keto tautomers interact with enzyme systems such as phenylalanine dehydrogenase or carboxypeptidase A whereas enol tautomers are potential inhibitors on the phenylpyruvate tautomerase activity catalysed by Macrophage Migration Inhibitory Factor (MIF). MIF being a key molecule in immune and inflammatory processes several structures with reasonable interaction with MIF and protocol for specific synthesis are presented. Birkhaeuser Boston 2004.
Design and synthesis of 2,4-difluorophenylpyruvic acid and of its azlactone precursor for macrophage migration inhibitory factor (MIF) tautomerase activity
Haasbroek,Oliver,Carpy
, p. 89 - 94 (2007/10/03)
The macrophage migration inhibitory factor (MIF) is an important cytokine implicated in several diseases and currently a target for drug development. This study aimed to synthesize phenylpyruvic acid like structures that fit the molecular requirements of
