676530-01-1Relevant articles and documents
Design and synthesis of 2,4-difluorophenylpyruvic acid and of its azlactone precursor for macrophage migration inhibitory factor (MIF) tautomerase activity
Haasbroek,Oliver,Carpy
, p. 89 - 94 (2004)
The macrophage migration inhibitory factor (MIF) is an important cytokine implicated in several diseases and currently a target for drug development. This study aimed to synthesize phenylpyruvic acid like structures that fit the molecular requirements of