914088-75-8Relevant academic research and scientific papers
9-Cyano-1-azapaullone (Cazpaullone), a Glycogen Synthase Kinase-3 (GSK-3) inhibitor activating pancreatic β cell protection and replication
Stukenbrock, Hendrik,Mussmann, Rainer,Geese, Marcus,Ferandin, Yoan,Lozach, Olivier,Lemcke, Thomas,Kegel, Simone,Lomow, Alexander,Burk, Ulrike,Dohrmann, Cord,Meijer, Laurent,Austen, Matthias,Kunick, Conrad
, p. 2196 - 2207 (2008/12/22)
Recently, the serine/threonine kinase glycogen synthase kinase-3 (GSK-3) emerged as a regulator of pancreatic β cell growth and survival. On the basis of the previous observation that GSK-3 inhibitors like 1-azakenpaullone promote β cell protection and re
USE OF AZAPAULLONES FOR PREVENTING AND TREATING PANCREATIC AUTOIMMUNE DISORDERS
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Page/Page column 45, (2010/11/24)
This invention relates to the use of azapaullones, particularly in combination with immunomodulating agents, in the prevention, and/or treatment of pancreatic autoimmune disorders, e.g. type I diabetes or LADA and neurodegenerative disorders .
