6767-29-9

Upstream product

• 17078-28-3 2-[4-(dimethylamino)phenyl]acetic acid 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 50438-75-0 2-(4-dimethylaminophenyl)ethyl alcohol 
• 39552-81-3 methyl p-aminophenylacetate 
• 1197-55-3 4-aminophenylacetic acid 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 96-34-4 methyl chloroacetate 

Downstream Products

• 51337-18-9 {4-[2,2-Bis-(4-methoxy-phenyl)-vinyl]-phenyl}-dimethyl-amine 
• 259191-69-0 5-(4-Dimethylamino-benzyl)-3-(1-methyl-4-phenyl-butyl)-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 
• 949168-20-1 methyl 5-chloro-2-(4-dimethylaminophenyl)pentanoate 
• 51337-21-4 {4-[2,2-Bis-(4-ethoxy-phenyl)-ethyl]-phenyl}-dimethyl-amine 
• 51337-20-3 {4-[2,2-Bis-(4-methoxy-phenyl)-ethyl]-phenyl}-dimethyl-amine 
• 99067-96-6 4-(dimethylamino)benzylisocyanate 
• 51337-19-0 {4-[2,2-Bis-(4-ethoxy-phenyl)-vinyl]-phenyl}-dimethyl-amine 
• 100133-14-0 (4-dimethylamino-phenyl)-acetic acid hydrazide 

Relevant academic research and scientific papers

Additive-freeN-methylation of amines with methanol over supported iridium catalyst

An efficient and versatile zinc oxide-supported iridium (Ir/ZnO) catalyst was developed to catalyze the additive-freeN-methylation of amines with methanol. Mechanistic studies suggested that the high catalytic reactivity is rooted in the small sizes (1.4 nm) of Ir nanoparticles and the high ratio (93%) of oxidized iridium species (IrOx, Ir3+and Ir4+) on the catalyst. Moreover, the delicate cooperation between the IrOxand ZnO support also promoted its high reactivity. The selectivity of this catalyticN-methylation was controllable between dimethylation and monomethylation by carefully tuning the catalyst loading and reaction solvent. Specifically, neat methanol with high catalyst loading (2 mol% Ir) favored the formation ofN,N-dimethylated amine, while the mesitylene/methanol mixture with low catalyst loading (0.5 mol% Ir) was prone to producing mono-N-methylated amines. An environmentally benign continuous flow system with a recycled mode was also developed for the efficient production ofN-methylated amines. With optimal flow rates and amine concentrations, a variety ofN-methylamines were produced with good to excellent yields in this Ir/ZnO-based flow system, providing a starting point for the clean and efficient production ofN-methylamines with this cost-effective chemical process.

Conversion of primary alcohols and aldehydes into methyl esters by ruthenium-catalysed hydrogen transfer reactions

Alcohols and aldehydes are oxidised to the corresponding methyl esters by reaction with methanol in the presence of crotononitrile as a hydrogen acceptor using a catalyst combination of Ru(PPh3)3(CO)H2 with xantphos. Georg Thieme Verlag Stuttgart.

Oxidation of primary alcohols to methyl esters by hydrogen transfer

The oxidation of alcohols in the presence of methanol has been achieved using a ruthenium catalyst with crotononitrile as the hydrogen acceptor. The Royal Society of Chemistry.

Multi-cyclic cinnamide derivatives

The present invention provides a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group that may be substituted with a C1-6 alkyl group, or the like, Ar2 represents a phenyl group that may be substituted with a C1-6 alkoxy group, or the like, X1 represents a double bond or the like, and Het represents an imidazolyl group that may be substituted with a C1-6 alkyl group, or the like, which is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.

Nickel-catalyzed direct electrochemical cross-coupling between aryl halides and activated alkyl halides

The electrochemical reduction of a mixture of aryl halides and activated alkyl halides in DMF in the presence of catalytic amount of NiBr2bipy leads to cross-coupling products in good to high yields. The method applies to the synthesis of α-aryl ketones, α-aryl esters, and allylated compounds from readily available organic halides. Optimization of the process has been obtained by slowly adding the most reactive organic halide (usually the activated alkyl halide) during the electrolysis which is best conducted at 70 °C when aryl bromides are involved.