67720-34-7

Upstream product

• 855842-55-6 1-(7-methoxy-1-oxa-4-thia-spiro[4.5]dec-6-yl)-ethanol 
• 74457-12-8 2-(1-hydroxyethyl)-3-(methylseleno)cyclohexanone 
• 74457-11-7 2-(1-Hydroxy-ethyl)-3-phenylsulfanyl-cyclohexanone 
• 930-68-7 cyclohexenone 
• 75-07-0 acetaldehyde 
• 67-64-1 acetone 
• 858195-01-4 6-acetyl-7-methoxy-1-oxa-4-thia-spiro[4.5]decane 
• 875226-15-6 6-ethynyl-1-oxa-4-thia-spiro[4.5]decan-6-ol 

Downstream Products

• 78344-00-0 (6-oxocyclohex-1-en-1-yl)-2-ethyl acetate 
• 59697-64-2 (E)-2-ethylidene-3-methylcyclohexanone 
• 1204473-83-5 (E)-2-ethylidene-3-(2-naphthyl)cyclohexanone 
• 1204473-81-3 (E)-2-ethylidene-3-(4-methoxyphenyl)cyclohexanone 
• 1204473-82-4 (E)-2-ethylidene-3-(4-trifluoromethylphenyl)cyclohexanone 
• 1204512-33-3 (E)-2-ethylidene-3-phenylcyclohexanone 
• 1204473-95-9 (E)-2-ethylidene-3-(4-bromophenyl)cyclohexanone 
• 1204473-80-2 (R,E)-2-ethylidene-3-phenylcyclohexanone 
• 135507-86-7 (R)-2-(1-hydroxyethyl)cyclohex-2-enone 
• 1460272-00-7 2-[1-(propylsulfanyl)ethyl]cyclohex-2-en-1-one 

Relevant academic research and scientific papers

Substituted (E)-2-methylene-3,4-cyclohexenones through direct and convenient synthesis from cyclohexenone-MBH alcohol in the presence of DMAP

An unexpected and effective DMAP catalyzed one-step construction of 3,4-cyclohexenone skeleton from simple and easily available cyclohexenone-MBH alcohol has been disclosed. A series of substituted (E)-2-methylene-3,4-cyclo-hexenones have been effectively prepared in excellent yields (up to 93 %) under convenient reaction conditions. Succesful scale-up preparation and synthetic transformations have demonstrated the potentials of this new protocol.

A Metal-Free Synthesis of 2-Alkyl(or Aryl) Thiomethyl-2-cyclohexenones from Cyclic Morita–Baylis–Hillman Bromides

Under mild conditions, an efficient and rapid S-allylation of thiols with cyclic Morita–Baylis–Hillman (MBH) bromides without the need of a transition-metal catalyst or an expensive additive is described herein. Treatment of the MBH bromides with various

Transition-metal-free nucleophilic allylic substitutions of Morita–Baylis–Hillman bromides with aliphatic and aromatic amines

A simple protocol for the preparation of functionalized allylic amines under mild, transition-metal-free conditions from the reaction of Morita–Baylis–Hillman (MBH) bromides with amines is described herein. The treatment of the MBH bromides with various amines in the presence of NaI and Et3N in aqueous acetone solution and at room temperature affords the corresponding functionalized allyl amines in moderate to good yields (45–87%). The reaction is rapid and carried out at room temperature.

Imidazole-catalysed Baylis-Hillman reactions: A new route to allylic alcohols from aldehydes and cyclic enones

An efficient one-pot synthesis of cyclic Baylis-Hillman adducts is described. An imidazole-catalysed coupling reaction between cyclic enones and both aliphatic and aromatic aldehydes leads to allylic alcohols in moderate to good yields.

Aldol Reaction of Aluminium Enolate Resulting from 1,4-Addition of R2AlX to α,β-Unsaturated Carbonyl Compound. A 1-Acylethenyl Anion Equivalent

Organoaluminium reagents R2AlX (X=SPh, SeMe) easily add to α,β-unsaturated carbonyl compounds in 1,4-fashion.The resulting aluminium enolates react with aldehydes to give aldol adducts in fair to good yields.Formal elimination of HX from the adducts provi

ALDOL REACTION OF ALUMINIUM ENOLATE RESULTING FROM 1,4-ADDITION OF Me2AlSPh TO α,β-UNSATURATED CARBONYL COMPOUND. A 1-ACYLETHENYL ANION EQUIVALENT

Me2AlSPh or Me2AlSeMe adds to α,β-unsaturated carbonyl compounds in 1,4-fashion.The resulting aluminium enolates react with aldehydes effectively to afford the adducts of the title anion after formal PhSH (or MeSeH)-elimination