677297-90-4

Basic information

• Product Name: 1,2,4-Benzotriazin-3-amine, 7-(2,6-dimethylphenyl)-
• CAS NO: 677297-90-4
• Molecular Formula: C15H14N4
• Molecular Weight: 250.303
• Mol File: 677297-90-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,2,4-Benzotriazin-3-amine, 7-(2,6-dimethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Benzotriazin-3-amine, 7-(2,6-dimethylphenyl)-(677297-90-4)
• EPA Substance Registry System: 1,2,4-Benzotriazin-3-amine, 7-(2,6-dimethylphenyl)-(677297-90-4)

Safety Data

• Hazardous Substances Data: 677297-90-4(Hazardous Substances Data)

Upstream product

• 6298-38-0 7-bromo-1-oxido-1,2,4-benzotriazin-1-ium-3-amine 
• 500889-65-6 3-amino-7-bromobenzo-1,2,4-triazine 
• 100379-00-8 2,6-dimethylbenzene boronic acid 
• 875-51-4 4-Bromo-2-nitroaniline 
• 119707-95-8 2-nitro-4-bromophenylguanidine 
• 52409-22-0 tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ 
• 64-17-5 ethanol 
• 127-19-5 N,N-dimethyl acetamide 

Relevant articles and documents

Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine-a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays

We describe the identification of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine (3), a potent, orally active Src inhibitor with desirable PK properties, demonstrated activity in human tumor cell lines

Benzotriazine inhibitors of kinases

The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.