677323-52-3

Upstream product

• 100-39-0 benzyl bromide 
• 118-92-3 anthranilic acid 

Downstream Products

• 677323-53-4 dimethyl 2-(2-N,N-dibenzylaminophenyl)-2-oxoethylphosphonate 
• 677323-56-7 (S)-Methoxy-phenyl-acetic acid (R)-1-(2-dibenzylamino-phenyl)-2-(dimethoxy-phosphoryl)-ethyl ester 
• 677323-55-6 (S)-Methoxy-phenyl-acetic acid (S)-1-(2-dibenzylamino-phenyl)-2-(dimethoxy-phosphoryl)-ethyl ester 
• 677323-49-8 dimethyl (R)-2-(2-N,N-dibenzylaminophenyl)-2-hydroxyethylphosphonate 
• 677323-48-7 dimethyl (S)-2-(2-N,N-dibenzylaminophenyl)-2-hydroxyethylphosphonate 
• 677323-54-5 dimethyl 2-(2-N,N-dibenzylaminophenyl)-2-hydroxyethylphosphonate 

Relevant academic research and scientific papers

Gas-phase domino cyclization of phosphonium ylides leading to the total synthesis of Eustifoline D

Six stabilised phosphonium ylides bearing ortho-benzylaminophenyl and cinnamoyl (or a heterocyclic analogue) groups have been prepared and upon flash vacuum pyrolysis at 800 °C were found to undergo cascade cyclization processes to give mainly 3-styrylquinolines but also in some cases ring-fused carbazoles and other fused-ring heterocyclic products. By starting with an appropriate ring-methylated precursor the natural product Eustifoline D was obtained in 19% yield in the pyrolysis in addition to the 3-(2-furylethenyl)quinoline (46%).

Preparation of dimethyl (R)- and (S)-2-(2-aminophenyl)-2- hydroxyethylphosphonate from anthranilic acid

An efficient synthesis of both enantiomers of dimethyl δ-amino- β-hydroxyethylphosphonate 6 has been achieved starting from anthranilic acid, through the resolution of dimethyl (±)-2-(2-N,N- dibenzylaminophenyl)-2-hydroxyethylphosphonate 9 with (S)-O-meth