677325-00-7

Upstream product

• 173423-55-7 3-((tert-butyldimethylsilyl)oxy)-2-phenylpropan-1-ol 
• 618094-94-3 2-[3-[(tert-butyldimethylsilanyl)oxy]-2-phenylpropyl]isoindole-2,3-dione 
• 24424-99-5 di-tert-butyl dicarbonate 
• 677324-99-1 3-((tert-butyldimethylsilyl)oxy)-2-phenylpropan-1-amine 

Downstream Products

• 127087-62-1 (3-hydroxy-2-phenylpropyl)carbamic acid tert-butyl ester 
• 127087-63-2 (3-oxo-2-phenylpropyl)carbamic acid tert-butyl ester 
• 677325-03-0 hexahydro-4-hydroxy-5-phenylfuro[2,3-b]pyridine-7-carboxylic acid tert-butyl ester 
• 677325-04-1 hexahydro-4-oxo-5-phenylfuro[2,3-b]pyridine-7-carboxylic acid tert-butyl ester 
• 677325-02-9 [3-hydroxy-3-(tetrahydro-2-hydroxyfuran-3-yl)-2-phenylpropyl]carbamic acid tert-butyl ester 
• 677325-01-8 [3-hydroxy-3-(tetrahydro-2-oxofuran-3-yl)-2-phenylpropyl]carbamic acid tert-butyl ester 
• 677325-05-2 hexahydro-4-oxo-5-phenyl-3a,5-bis(phenylselanyl)furo[2,3-b]pyridine-7-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Model Studies and First Synthesis of the Antifungal and Antibacterial Agent Cladobotryal

The antifungal and antibacterial agent cladobotryal (1) was synthesized by a convergent route from lactone 31 and aldehyde 13, a key step in the elaboration of the pyridinone ring being conversion of a Boc group on nitrogen into a CO2SiPr-i3 group. The simple model compounds 9 and 10, representing the core of cladobotryal and of 5, respectively, were prepared as support studies for making the natural product.